The development of progressive osteopenia and osteoporosis (OP) is due to the imbalance between bone resorption and bone formation, determining a lower bone resistance, major risks of fractures, with consequent pain and functional limitations. Flavonoids, a class of polyphenols, have been extensively studied for their therapeutic activities against bone resorption, but less attention has been given to a whole series of molecules belonging to the polyphenolic compounds. However, these classes have begun to be studied for the treatment of OP. In this systematic review, comprehensive information is provided on non-flavonoid polyphenolic compounds, and we highlight pathways implicated in the action of these molecules that act often epigenetically, and their possible use for OP treatment and prevention.

Bellavia, D., Caradonna, F., Dimarco, E., Costa, V., Carina, V., De Luca, A., et al. (2021). Non-flavonoid Polyphenols in Osteoporosis: Preclinical Evidence. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1-15 [10.1016/j.tem.2021.03.008].

Non-flavonoid Polyphenols in Osteoporosis: Preclinical Evidence

Caradonna, Fabio;Gentile, Carla;
2021

Abstract

The development of progressive osteopenia and osteoporosis (OP) is due to the imbalance between bone resorption and bone formation, determining a lower bone resistance, major risks of fractures, with consequent pain and functional limitations. Flavonoids, a class of polyphenols, have been extensively studied for their therapeutic activities against bone resorption, but less attention has been given to a whole series of molecules belonging to the polyphenolic compounds. However, these classes have begun to be studied for the treatment of OP. In this systematic review, comprehensive information is provided on non-flavonoid polyphenolic compounds, and we highlight pathways implicated in the action of these molecules that act often epigenetically, and their possible use for OP treatment and prevention.
Settore BIO/18 - Genetica
Settore BIO/10 - Biochimica
Settore BIO/13 - Biologia Applicata
Bellavia, D., Caradonna, F., Dimarco, E., Costa, V., Carina, V., De Luca, A., et al. (2021). Non-flavonoid Polyphenols in Osteoporosis: Preclinical Evidence. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1-15 [10.1016/j.tem.2021.03.008].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/513168
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