The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing high and rapid morbidity and mortality. Immune system response plays a crucial role in controlling and resolving the viral infection. Exogenous or endogenous glucocorticoid excess is characterized by increased susceptibility to infections, due to impairment of the innate and adaptive immune system. In addition, diabetes, hypertension, obesity and thromboembolism are conditions overrepresented in patients with hypercortisolism. Thus patients with chronic glucocorticoid (GC) excess may be at high risk of developing COVID-19 infection with a severe clinical course. Care and control of all comorbidities should be one of the primary goals in patients with hypercortisolism requiring immediate and aggressive treatment. The European Society of Endocrinology (ESE), has recently commissioned an urgent clinical guidance document on management of Cushing’s syndrome in a COVID-19 period. In this review, we aim to discuss and expand some clinical points related to GC excess that may have an impact on COVID-19 infection, in terms of both contagion risk and clinical outcome. This document is addressed to all specialists who approach patients with endogenous or exogenous GC excess and COVID-19 infection.

Guarnotta V., Ferrigno R., Martino M., Barbot M., Isidori A.M., Scaroni C., et al. (2020). Glucocorticoid excess and COVID-19 disease. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS [10.1007/s11154-020-09598-x].

Glucocorticoid excess and COVID-19 disease

Guarnotta V.
Primo
;
Ferrante A.;Arnaldi G.;Giordano C.
Ultimo
2020-01-01

Abstract

The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing high and rapid morbidity and mortality. Immune system response plays a crucial role in controlling and resolving the viral infection. Exogenous or endogenous glucocorticoid excess is characterized by increased susceptibility to infections, due to impairment of the innate and adaptive immune system. In addition, diabetes, hypertension, obesity and thromboembolism are conditions overrepresented in patients with hypercortisolism. Thus patients with chronic glucocorticoid (GC) excess may be at high risk of developing COVID-19 infection with a severe clinical course. Care and control of all comorbidities should be one of the primary goals in patients with hypercortisolism requiring immediate and aggressive treatment. The European Society of Endocrinology (ESE), has recently commissioned an urgent clinical guidance document on management of Cushing’s syndrome in a COVID-19 period. In this review, we aim to discuss and expand some clinical points related to GC excess that may have an impact on COVID-19 infection, in terms of both contagion risk and clinical outcome. This document is addressed to all specialists who approach patients with endogenous or exogenous GC excess and COVID-19 infection.
2020
Settore MED/13 - Endocrinologia
Guarnotta V., Ferrigno R., Martino M., Barbot M., Isidori A.M., Scaroni C., et al. (2020). Glucocorticoid excess and COVID-19 disease. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS [10.1007/s11154-020-09598-x].
File in questo prodotto:
File Dimensione Formato  
ART 1 INSERITO.pdf

accesso aperto

Tipologia: Versione Editoriale
Dimensione 2.31 MB
Formato Adobe PDF
2.31 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/510615
Citazioni
  • ???jsp.display-item.citation.pmc??? 27
  • Scopus 38
  • ???jsp.display-item.citation.isi??? 34
social impact