B lymphocytes are among the cell types whose effector functions are modulated by mast cells (MCs). The B/MC crosstalk emerged in several pathological settings, notably the colon of inflammatory bowel disease (IBD) patients is a privileged site in which MCs and IgA+ cells physically interact. Herein, by inducing conditional depletion of MCs in red MC and basophil (RMB) mice, we show that MCs control B cell distribution in the gut and IgA serum levels. Moreover, in dextran sulfate sodium (DSS)-treated RMB mice, the presence of MCs is fundamental for the enlargement of the IgA+ population in the bowel and the increase of systemic IgA production. Since both conventional B-2 and peritoneal-derived B cells populate the intestine and communicate with MCs in physiological conditions and during inflammation, we further explored this interplay through the use of co-cultures. We show that MCs finely regulate different aspects of splenic B cell biology while peritoneal B cells are unresponsive to the supporting effects provided by MCs. Interestingly, peritoneal B cells induce a pro-inflammatory skewing in MCs, characterized by increased ST2 and TNF-α expression. Altogether, this study uncovers the versatility of the B/MC liaison and highlights key aspects for the resolution of intestinal inflammation.
Valeri V., Tonon S., Vibhushan S., Gulino A., Belmonte B., Adori M., et al. (2021). Mast cells crosstalk with B cells in the gut and sustain IgA response in the inflamed intestine. EUROPEAN JOURNAL OF IMMUNOLOGY, 51(2), 445-458.
Data di pubblicazione: | 2021 | |
Titolo: | Mast cells crosstalk with B cells in the gut and sustain IgA response in the inflamed intestine | |
Autori: | ||
Citazione: | Valeri V., Tonon S., Vibhushan S., Gulino A., Belmonte B., Adori M., et al. (2021). Mast cells crosstalk with B cells in the gut and sustain IgA response in the inflamed intestine. EUROPEAN JOURNAL OF IMMUNOLOGY, 51(2), 445-458. | |
Rivista: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/eji.202048668 | |
Abstract: | B lymphocytes are among the cell types whose effector functions are modulated by mast cells (MCs). The B/MC crosstalk emerged in several pathological settings, notably the colon of inflammatory bowel disease (IBD) patients is a privileged site in which MCs and IgA+ cells physically interact. Herein, by inducing conditional depletion of MCs in red MC and basophil (RMB) mice, we show that MCs control B cell distribution in the gut and IgA serum levels. Moreover, in dextran sulfate sodium (DSS)-treated RMB mice, the presence of MCs is fundamental for the enlargement of the IgA+ population in the bowel and the increase of systemic IgA production. Since both conventional B-2 and peritoneal-derived B cells populate the intestine and communicate with MCs in physiological conditions and during inflammation, we further explored this interplay through the use of co-cultures. We show that MCs finely regulate different aspects of splenic B cell biology while peritoneal B cells are unresponsive to the supporting effects provided by MCs. Interestingly, peritoneal B cells induce a pro-inflammatory skewing in MCs, characterized by increased ST2 and TNF-α expression. Altogether, this study uncovers the versatility of the B/MC liaison and highlights key aspects for the resolution of intestinal inflammation. | |
Settore Scientifico Disciplinare: | Settore MED/08 - Anatomia Patologica | |
Appare nelle tipologie: | 1.01 Articolo in rivista |
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