The ethnobotany, phytochemistry and biological properties of genus Ferulago – A review

Ethnopharmacological relevance: The genus Ferulago, belonging to the Apiaceae family, is found mainly in the Mediterranean area, Southwest and Middle Asia, the Caucasus and North Africa. Since ancient times, species of this genus have been largely employed in traditional medicine for their biological properties such as antimicrobial, anti-inflammatory, antispasmodic, insecticidal, and anti-malaria, cholinesterase inhibition effects, etc. Aims: The scope of this paper is to present a comprehensive respect review of this interesting genus including traditional uses, chemical composition of volatile and non-volatile metabolites, and in vitro and in vivo biological properties either utilizing the crude extracts or essential oils, or the single isolated compounds. Furthermore, critical considerations of the published data have been highlighted by comparing them with the results obtained from species of other genus belonging to the Apiaceae family. Materials and methods: The available information on these genera was collected from scientific databases and cover from 1967 up to 2020. The following electronic databases were used: PubMed, SciFinder, Science Direct, Scopus, Web of Science and Google Scholar. The search terms used for this review included Ferulago, all the botanical names of the species, both accepted names or synonyms, essential oils, volatile components, traditional uses, activity, pharmacology, and toxicity. No limitations were set for languages. A total of 230 articles were included in the present review. Results: Researches performed on either crude extracts, solvent fractions or isolated pure compounds from species of genus Ferulago showed several biological properties such as antibacterial, antifungal, antioxidant, antidiabetic, enzymatic, cytotoxic, anticancer, hepatoprotective, nephroprotective, antileishmanial, antimalarial, anticoagulant, anti-inflammatory, insecticidal, etc. Activities. Phytochemical investigations of Ferulago species have revealed that coumarins are the main constituents of the genera. A large number of flavonoids, terpenoids and other metabolites were also identified. Furthermore, a complete review on the essential oil composition of all the taxa studied so far has been also included. Conclusion: In the present study, we have provided scientific information and research developments on traditional uses, phytochemical profiles, biological activities and industrial practices on the Ferulago genus. The commercial use and the applications in agri-food sector of some of these species have been also considered. In fact, the various extracts and essential oils have been used as antioxidants and/or as antimicrobial agents, for the stabilization of sunflower and soybean oil, for food packagings, as antioxidants of mayonnaise and yogurt during their storage and, also, as economically valid source for obtaining single compounds, more expensive at a synthetic level.