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EnglishA simulative study of cancer growth dynamics in patients affected by Chronic Myeloid Leukemia (CML), under the effect of a targeted dosedependent continuous or pulsed therapy, is presented. We have developed a model for the dynamics of CML in which thestochastic evolution of white blood cell populations are simulated by adopting a Monte Carlo approach. Several scenarios in the evolutionary dynamics of white blood cells, as a consequence of the efficacy of the different modelled therapies, pulsed or continuous, are described. The best results, in terms of a permanent disappearance of the leukemic phenotype, are achieved with a continuous therapy and higher dosage. However, our findings demonstrate that an intermittent therapy could represent a valid choice in patients with high risk of toxicity, when a long-term therapy is considered. A suitably tuned pulsed therapy can enhance the treatment efficacy and reduce the percentage of patients developing resistance.
Pizzolato, N., PERSANO ADORNO, D., Valenti, D., & Spagnolo, B. (2010). Dose dependent survival response in chronic myeloid leukemia under continuous and pulsed targeted therapy. ACTA PHYSICA POLONICA B, 41(5), 1161-1170.
| Data di pubblicazione: | 2010 | |
| Titolo: | Dose dependent survival response in chronic myeloid leukemia under continuous and pulsed targeted therapy | |
| Autori: | ||
| Citazione: | Pizzolato, N., PERSANO ADORNO, D., Valenti, D., & Spagnolo, B. (2010). Dose dependent survival response in chronic myeloid leukemia under continuous and pulsed targeted therapy. ACTA PHYSICA POLONICA B, 41(5), 1161-1170. | |
| Rivista: | ||
| Abstract: | A simulative study of cancer growth dynamics in patients affected by Chronic Myeloid Leukemia (CML), under the effect of a targeted dosedependent continuous or pulsed therapy, is presented. We have developed a model for the dynamics of CML in which thestochastic evolution of white blood cell populations are simulated by adopting a Monte Carlo approach. Several scenarios in the evolutionary dynamics of white blood cells, as a consequence of the efficacy of the different modelled therapies, pulsed or continuous, are described. The best results, in terms of a permanent disappearance of the leukemic phenotype, are achieved with a continuous therapy and higher dosage. However, our findings demonstrate that an intermittent therapy could represent a valid choice in patients with high risk of toxicity, when a long-term therapy is considered. A suitably tuned pulsed therapy can enhance the treatment efficacy and reduce the percentage of patients developing resistance. | |
| Settore Scientifico Disciplinare: | Settore FIS/02 - Fisica Teorica, Modelli E Metodi Matematici Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin) | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/10447/50179
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