A simulative study of cancer growth dynamics in patients affected by Chronic Myeloid Leukemia (CML), under the effect of a targeted dosedependent continuous or pulsed therapy, is presented. We have developed a model for the dynamics of CML in which thestochastic evolution of white blood cell populations are simulated by adopting a Monte Carlo approach. Several scenarios in the evolutionary dynamics of white blood cells, as a consequence of the efficacy of the different modelled therapies, pulsed or continuous, are described. The best results, in terms of a permanent disappearance of the leukemic phenotype, are achieved with a continuous therapy and higher dosage. However, our findings demonstrate that an intermittent therapy could represent a valid choice in patients with high risk of toxicity, when a long-term therapy is considered. A suitably tuned pulsed therapy can enhance the treatment efficacy and reduce the percentage of patients developing resistance.

Pizzolato, N., Persano Adorno, D., Valenti, D., Spagnolo, B. (2010). Dose dependent survival response in chronic myeloid leukemia under continuous and pulsed targeted therapy. ACTA PHYSICA POLONICA B, 41(5), 1161-1170.

Dose dependent survival response in chronic myeloid leukemia under continuous and pulsed targeted therapy

PIZZOLATO, Nicola;PERSANO ADORNO, Dominique;VALENTI, Davide;SPAGNOLO, Bernardo
2010-01-01

Abstract

A simulative study of cancer growth dynamics in patients affected by Chronic Myeloid Leukemia (CML), under the effect of a targeted dosedependent continuous or pulsed therapy, is presented. We have developed a model for the dynamics of CML in which thestochastic evolution of white blood cell populations are simulated by adopting a Monte Carlo approach. Several scenarios in the evolutionary dynamics of white blood cells, as a consequence of the efficacy of the different modelled therapies, pulsed or continuous, are described. The best results, in terms of a permanent disappearance of the leukemic phenotype, are achieved with a continuous therapy and higher dosage. However, our findings demonstrate that an intermittent therapy could represent a valid choice in patients with high risk of toxicity, when a long-term therapy is considered. A suitably tuned pulsed therapy can enhance the treatment efficacy and reduce the percentage of patients developing resistance.
Settore FIS/02 - Fisica Teorica, Modelli E Metodi Matematici
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Pizzolato, N., Persano Adorno, D., Valenti, D., Spagnolo, B. (2010). Dose dependent survival response in chronic myeloid leukemia under continuous and pulsed targeted therapy. ACTA PHYSICA POLONICA B, 41(5), 1161-1170.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/50179
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