Background and aim: Nonalcoholic fatty liver (NAFL) is a major cause of liver disease worldwide leading also to a higher risk of cardiovascular events. We aimed to evaluate the impact of fatty liver and fibrosis on cardiovascular risk factors in a general population. Materials and methods: 604 subjects included in the communitybased ABCD (Alimentazione, Benessere Cardiovascolare e Diabete) study were recruited. Steatosis (CAP >288 dB/m) and fibrosis (>8.7 KPa by M and >7.2 KPa by XL probe) were assessed with FibroScan. Cardiovascular risk was evaluated by the Atherosclerotic Cardiovascular Disease (ASCVD) risk estimator and defined low if <5%, borderline if 5%-7.4%, intermediate if 7.5%-19.9% and high if ≥20%. Intima-media thickness (IMT) was measured with ultrasound (US). Multivariate linear, ordinal and logistic regression analyses were used to identify predictors of CV risk and IMT. Results: Prevalence of steatosis and of fibrosis in this cohort were 28.6% and 6.6%, respectively. Subjects with NAFL, when compared to those without, had on average a higher IMT (0.75 vs 0.68 mm; p=0.002) and more frequently an IMT≥1mm (15.6% vs 10.4%;p=0.07), these associations being lost after adjusting for ASCVD score (p=0.66 for IMT; OR1.14,95%C.I.0.64-2.02,p=0.64 for IMT≥1mm). Patients with significant fibrosis, respect to their counterpart, had also significant higher IMT (0.8 vs 0.7 mm; p=0.005) and significant higher prevalence of IMT≥1mm (25% vs 10.9%;p=0.008) and these association were maintained after adjusting for confounders (p=0.04 for IMT;OR 2.60,95%C.I.1.10-6.12,p=0.02 for IMT≥1mm). ASCVD score was evaluated in patients with and without steatosis (Table 1) and significant fibrosis (Table 2). Notably, by ordinal regression analysis, both steatosis (OR 1.74,95%C.I.1.22-2.50, p=0.002) and significant

Pennisi, G., Buscemi, C., Buscemi, S., Di Marco, V., Liotta, C., Randazzo, C., et al. (2020). IMPACT OF NON-ALCOHOLIC FATTY LIVER DISEASE ON CARDIOVASCULAR RISK IN A GENERAL POPULATION. DIGESTIVE AND LIVER DISEASE, 52, 164-165 [10.1016/S1590-8658(20)30860-4].

IMPACT OF NON-ALCOHOLIC FATTY LIVER DISEASE ON CARDIOVASCULAR RISK IN A GENERAL POPULATION

Pennisi, G;Buscemi, S;Di Marco, V;Randazzo, C;Petta, S
2020

Abstract

Background and aim: Nonalcoholic fatty liver (NAFL) is a major cause of liver disease worldwide leading also to a higher risk of cardiovascular events. We aimed to evaluate the impact of fatty liver and fibrosis on cardiovascular risk factors in a general population. Materials and methods: 604 subjects included in the communitybased ABCD (Alimentazione, Benessere Cardiovascolare e Diabete) study were recruited. Steatosis (CAP >288 dB/m) and fibrosis (>8.7 KPa by M and >7.2 KPa by XL probe) were assessed with FibroScan. Cardiovascular risk was evaluated by the Atherosclerotic Cardiovascular Disease (ASCVD) risk estimator and defined low if <5%, borderline if 5%-7.4%, intermediate if 7.5%-19.9% and high if ≥20%. Intima-media thickness (IMT) was measured with ultrasound (US). Multivariate linear, ordinal and logistic regression analyses were used to identify predictors of CV risk and IMT. Results: Prevalence of steatosis and of fibrosis in this cohort were 28.6% and 6.6%, respectively. Subjects with NAFL, when compared to those without, had on average a higher IMT (0.75 vs 0.68 mm; p=0.002) and more frequently an IMT≥1mm (15.6% vs 10.4%;p=0.07), these associations being lost after adjusting for ASCVD score (p=0.66 for IMT; OR1.14,95%C.I.0.64-2.02,p=0.64 for IMT≥1mm). Patients with significant fibrosis, respect to their counterpart, had also significant higher IMT (0.8 vs 0.7 mm; p=0.005) and significant higher prevalence of IMT≥1mm (25% vs 10.9%;p=0.008) and these association were maintained after adjusting for confounders (p=0.04 for IMT;OR 2.60,95%C.I.1.10-6.12,p=0.02 for IMT≥1mm). ASCVD score was evaluated in patients with and without steatosis (Table 1) and significant fibrosis (Table 2). Notably, by ordinal regression analysis, both steatosis (OR 1.74,95%C.I.1.22-2.50, p=0.002) and significant
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
Settore MED/12 - Gastroenterologia
26th National Congress of Digestive Diseases Extraordinary edition
07 october 2020
Pennisi, G., Buscemi, C., Buscemi, S., Di Marco, V., Liotta, C., Randazzo, C., et al. (2020). IMPACT OF NON-ALCOHOLIC FATTY LIVER DISEASE ON CARDIOVASCULAR RISK IN A GENERAL POPULATION. DIGESTIVE AND LIVER DISEASE, 52, 164-165 [10.1016/S1590-8658(20)30860-4].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/493772
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