Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
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EnglishThe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a neurotropic virus with a high neuroinvasive potential. Indeed, more than one-third of patients develop neurological symptoms, including confusion, headache, and hypogeusia/ageusia. However, long-term neurological consequences have received little interest compared to respiratory, cardiovascular, and renal manifestations. Several mechanisms have been proposed to explain the potential SARS-CoV-2 neurological injury that could lead to the development of neurodegenerative diseases, including Alzheimer's Disease (AD). A mutualistic relationship between AD and COVID-19 seems to exist. On the one hand, COVID-19 patients seem to be more prone to developing AD. On the other hand, AD patients could be more susceptible to severe COVID-19. In this review, we sought to provide an overview on the relationship between AD and COVID-19, focusing on the potential role of biomarkers, which could represent precious tool for early identification of COVID-19 patients at high risk of developing AD.
Marcello Ciaccio, Bruna Lo Sasso, Concetta Scazzone, Caterina Maria Gambino, Anna Maria Ciaccio, Giulia Bivona, et al. (2021). COVID-19 and Alzheimer's Disease.
| Data di pubblicazione: | 2021 | |
| Titolo: | COVID-19 and Alzheimer's Disease | |
| Autori: | ||
| Citazione: | Marcello Ciaccio, Bruna Lo Sasso, Concetta Scazzone, Caterina Maria Gambino, Anna Maria Ciaccio, Giulia Bivona, et al. (2021). COVID-19 and Alzheimer's Disease. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/brainsci11030305 | |
| Abstract: | The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a neurotropic virus with a high neuroinvasive potential. Indeed, more than one-third of patients develop neurological symptoms, including confusion, headache, and hypogeusia/ageusia. However, long-term neurological consequences have received little interest compared to respiratory, cardiovascular, and renal manifestations. Several mechanisms have been proposed to explain the potential SARS-CoV-2 neurological injury that could lead to the development of neurodegenerative diseases, including Alzheimer's Disease (AD). A mutualistic relationship between AD and COVID-19 seems to exist. On the one hand, COVID-19 patients seem to be more prone to developing AD. On the other hand, AD patients could be more susceptible to severe COVID-19. In this review, we sought to provide an overview on the relationship between AD and COVID-19, focusing on the potential role of biomarkers, which could represent precious tool for early identification of COVID-19 patients at high risk of developing AD. | |
| Appare nelle tipologie: | 1.09 Review essay (rassegna critica) |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| COVID-19 and Alzheimer’s Disease.pdf | Versione Editoriale | Open Access Visualizza/Apri |
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