Diffuse large B-cell lymphoma (DLBCL) is the commonest type of lymphomas, accounting for 30%-40% of new cases each year. Despite the big improvements achieved in the treatment, still 25–40% of patients still succumb due to refractory or relapsed disease. This highlights the need of new drugs for this cancer. The marine environment has recently been recognized as a source of anti-cancer compounds, as demonstrated by different marine drugs approved by different regulatory agencies (trabectedin, cytarabine, eribulin, plitidepsin) or as components of antibody drug conjugates for lymphoma patients (monomethyl auristatin E in polatuzumab vedotin and brentuximab vedotin). Here, we present a large screening of fractions obtained from different marine invertebrates collected in Ireland and in the Pacific Ocean on DLBCL cell lines

Spriano F., Barreca M., Miguel-Gordo M., O'Brien S., Arribas A.J., Jennings L., et al. (2020). Screening of fractions from marine sponges and other invertebrates to identify new lead compounds with anti-tumor activity in lymphoma models. EUROPEAN JOURNAL OF CANCER, 138(2), 17-17 [10.1016/S0959-8049(20)31110-2].

Screening of fractions from marine sponges and other invertebrates to identify new lead compounds with anti-tumor activity in lymphoma models

Barreca M.;
2020

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the commonest type of lymphomas, accounting for 30%-40% of new cases each year. Despite the big improvements achieved in the treatment, still 25–40% of patients still succumb due to refractory or relapsed disease. This highlights the need of new drugs for this cancer. The marine environment has recently been recognized as a source of anti-cancer compounds, as demonstrated by different marine drugs approved by different regulatory agencies (trabectedin, cytarabine, eribulin, plitidepsin) or as components of antibody drug conjugates for lymphoma patients (monomethyl auristatin E in polatuzumab vedotin and brentuximab vedotin). Here, we present a large screening of fractions obtained from different marine invertebrates collected in Ireland and in the Pacific Ocean on DLBCL cell lines
32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
Virtual Conference
24-25/10/2020
Spriano F., Barreca M., Miguel-Gordo M., O'Brien S., Arribas A.J., Jennings L., et al. (2020). Screening of fractions from marine sponges and other invertebrates to identify new lead compounds with anti-tumor activity in lymphoma models. EUROPEAN JOURNAL OF CANCER, 138(2), 17-17 [10.1016/S0959-8049(20)31110-2].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/481617
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