Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. The current treatment regimes for glioblastoma demonstrated a low efficiency and offer a poor prognosis. Advancements in conventional treatment strategies have only yielded modest improvements in overall survival. The heat shockproteins, heme oxygenase-1 (HO-1) and Hsp90, serve these pivotal roles in tumor cells and have been identified as effective targets for developing therapeutics. This topic review summarizes the current preclinical and clinical evidences and rationale to define the potential of HO-1 and Hsp90 in GBM progression and chemoresistance.

Castracani C.C., Di Rosa M., Rappa F., Bono T., Furneri P.M., Avola R., et al. (2017). Role of heme oxygenase-1 (HSP32) and HSP90 in glioblastoma [10.3269/1970-5492.2017.12.21].

Role of heme oxygenase-1 (HSP32) and HSP90 in glioblastoma

Rappa F.;
2017

Abstract

Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. The current treatment regimes for glioblastoma demonstrated a low efficiency and offer a poor prognosis. Advancements in conventional treatment strategies have only yielded modest improvements in overall survival. The heat shockproteins, heme oxygenase-1 (HO-1) and Hsp90, serve these pivotal roles in tumor cells and have been identified as effective targets for developing therapeutics. This topic review summarizes the current preclinical and clinical evidences and rationale to define the potential of HO-1 and Hsp90 in GBM progression and chemoresistance.
Castracani C.C., Di Rosa M., Rappa F., Bono T., Furneri P.M., Avola R., et al. (2017). Role of heme oxygenase-1 (HSP32) and HSP90 in glioblastoma [10.3269/1970-5492.2017.12.21].
File in questo prodotto:
File Dimensione Formato  
EMBJ_policy.JPG

Solo gestori archvio

Descrizione: Licenza CC come da sito dell'editore
Tipologia: Contratto con l'editore (ATTENZIONE: NON TRASFERIRE A SITO DOCENTE)
Dimensione 133.84 kB
Formato JPEG
133.84 kB JPEG   Visualizza/Apri   Richiedi una copia
k2_attachments_Castruccio_21.pdf

accesso aperto

Descrizione: versione editoriale
Tipologia: Versione Editoriale
Dimensione 255.31 kB
Formato Adobe PDF
255.31 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/479244
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact