Flexible mats as promising antimicrobial systems via integration of Thymus capitatus (L.) essential oil into PLA

Scaffaro, R; Maio, A; Manuela, D; Lopresti, F; Andreana, M; Bruno, M; Antonia, N

doi:10.2217/fmb-2019-0291

To develop electrospun mats loaded with Thymus capitatus (L.) essential oil (ThymEO) and to study their morpho-mechanical and antimicrobial properties. Materials & methods: Poly(lactic acid) (PLA) mats containing ThymEO were prepared by electrospinning. The effect of ThymEO on the morpho-mechanical properties of fibers was assayed by scanning electron microscopy and dynamometer measurements. The antimicrobial activity of ThymEO delivered either in liquid or vapor phase was assessed through killing curves and invert Petri dishes method. The cytotoxicity was also investigated. Results: The mechanical properties were enhanced by integrating ThymEO into PLA. Both liquid and vapors of ThymEO released from mats caused reductions of microbial viable cells. Negligible cytotoxicity was demonstrated. Conclusion: PLA/ThymEO delivery systems could be suitable for treating microbial infections.

Roberto Scaffaro, A.M. (2020). Flexible mats as promising antimicrobial systems via integration of Thymus capitatus (L.) essential oil into PLA. FUTURE MICROBIOLOGY, 15(14), 1379-1392.

Data di pubblicazione:	2020
Titolo:	Flexible mats as promising antimicrobial systems via integration of Thymus capitatus (L.) essential oil into PLA
Autori:	SCAFFARO, Roberto MAIO, Andrea Manuela D’Arrigo Lopresti, Francesco Andreana Marino BRUNO, Maurizio Antonia Nostro (Corresponding) mostra contributor esterni nascondi contributor esterni
Citazione:	Roberto Scaffaro, A.M. (2020). Flexible mats as promising antimicrobial systems via integration of Thymus capitatus (L.) essential oil into PLA. FUTURE MICROBIOLOGY, 15(14), 1379-1392.
Rivista:	FUTURE MICROBIOLOGY
Digital Object Identifier (DOI):	http://dx.doi.org/10.2217/fmb-2019-0291
Abstract:	To develop electrospun mats loaded with Thymus capitatus (L.) essential oil (ThymEO) and to study their morpho-mechanical and antimicrobial properties. Materials & methods: Poly(lactic acid) (PLA) mats containing ThymEO were prepared by electrospinning. The effect of ThymEO on the morpho-mechanical properties of fibers was assayed by scanning electron microscopy and dynamometer measurements. The antimicrobial activity of ThymEO delivered either in liquid or vapor phase was assessed through killing curves and invert Petri dishes method. The cytotoxicity was also investigated. Results: The mechanical properties were enhanced by integrating ThymEO into PLA. Both liquid and vapors of ThymEO released from mats caused reductions of microbial viable cells. Negligible cytotoxicity was demonstrated. Conclusion: PLA/ThymEO delivery systems could be suitable for treating microbial infections.
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http://hdl.handle.net/10447/476637

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