To develop electrospun mats loaded with Thymus capitatus (L.) essential oil (ThymEO) and to study their morpho-mechanical and antimicrobial properties. Materials & methods: Poly(lactic acid) (PLA) mats containing ThymEO were prepared by electrospinning. The effect of ThymEO on the morpho-mechanical properties of fibers was assayed by scanning electron microscopy and dynamometer measurements. The antimicrobial activity of ThymEO delivered either in liquid or vapor phase was assessed through killing curves and invert Petri dishes method. The cytotoxicity was also investigated. Results: The mechanical properties were enhanced by integrating ThymEO into PLA. Both liquid and vapors of ThymEO released from mats caused reductions of microbial viable cells. Negligible cytotoxicity was demonstrated. Conclusion: PLA/ThymEO delivery systems could be suitable for treating microbial infections.

Roberto Scaffaro, A.M. (2020). Flexible mats as promising antimicrobial systems via integration of Thymus capitatus (L.) essential oil into PLA. FUTURE MICROBIOLOGY, 15(14), 1379-1392 [10.2217/fmb-2019-0291].

Flexible mats as promising antimicrobial systems via integration of Thymus capitatus (L.) essential oil into PLA

Roberto Scaffaro;Andrea Maio;Francesco Lopresti;Maurizio Bruno;
2020

Abstract

To develop electrospun mats loaded with Thymus capitatus (L.) essential oil (ThymEO) and to study their morpho-mechanical and antimicrobial properties. Materials & methods: Poly(lactic acid) (PLA) mats containing ThymEO were prepared by electrospinning. The effect of ThymEO on the morpho-mechanical properties of fibers was assayed by scanning electron microscopy and dynamometer measurements. The antimicrobial activity of ThymEO delivered either in liquid or vapor phase was assessed through killing curves and invert Petri dishes method. The cytotoxicity was also investigated. Results: The mechanical properties were enhanced by integrating ThymEO into PLA. Both liquid and vapors of ThymEO released from mats caused reductions of microbial viable cells. Negligible cytotoxicity was demonstrated. Conclusion: PLA/ThymEO delivery systems could be suitable for treating microbial infections.
Roberto Scaffaro, A.M. (2020). Flexible mats as promising antimicrobial systems via integration of Thymus capitatus (L.) essential oil into PLA. FUTURE MICROBIOLOGY, 15(14), 1379-1392 [10.2217/fmb-2019-0291].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/476637
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