Biomaterial-based-scaffolds’ functions are to replace anatomical and functional features loss of an injured tissue. They can replace native tissue after their reabsorption. Material and methods. In our experimental procedures we utilized the PHEA-PLA+PCL scaffold in 2 female pigs to assess its resistance to bile and urine. Results. Both pigs survived to surgical procedures. After a month fibres appeared unchanged in term of form and dimension at electronic microscopy. Cells and ECM factors were founded inside the scaffold in a microscopical evaluation. Conclusion. Planar and tubular scaffolds were colonized by cells and extracellular matrix elements. The study conducted on pig suggested that this type of material can resist to the action of bile and urine. This material could be proposed as a tissue substitute.

Fazzotta, S., Buscemi, S., Palumbo, V., Damiano, G., Geraci, G., Licciardi, M., et al. (2020). Nanofibrillar scaffold resists to bile and urine action: experiences in pigs. KLINICESKAA I EKSPERIMENTALʹNAA HIRURGIA, 8(4), 29-34 [10.33029/2308-1198-2020-8-4-29-34].

Nanofibrillar scaffold resists to bile and urine action: experiences in pigs

Fazzotta, S.
;
Buscemi, S.;Palumbo, V. D.;Damiano, G.;Geraci, G.;Licciardi, M.;Palumbo, F. S.;Fiorica, C.;Cudia, B. M.;Genova, P.;Lo Monte, A I
2020-01-01

Abstract

Biomaterial-based-scaffolds’ functions are to replace anatomical and functional features loss of an injured tissue. They can replace native tissue after their reabsorption. Material and methods. In our experimental procedures we utilized the PHEA-PLA+PCL scaffold in 2 female pigs to assess its resistance to bile and urine. Results. Both pigs survived to surgical procedures. After a month fibres appeared unchanged in term of form and dimension at electronic microscopy. Cells and ECM factors were founded inside the scaffold in a microscopical evaluation. Conclusion. Planar and tubular scaffolds were colonized by cells and extracellular matrix elements. The study conducted on pig suggested that this type of material can resist to the action of bile and urine. This material could be proposed as a tissue substitute.
Settore MED/18 - Chirurgia Generale
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Fazzotta, S., Buscemi, S., Palumbo, V., Damiano, G., Geraci, G., Licciardi, M., et al. (2020). Nanofibrillar scaffold resists to bile and urine action: experiences in pigs. KLINICESKAA I EKSPERIMENTALʹNAA HIRURGIA, 8(4), 29-34 [10.33029/2308-1198-2020-8-4-29-34].
File in questo prodotto:
File Dimensione Formato  
Nanofibrilliarny karkas ustoychiv.pdf.pdf

accesso aperto

Descrizione: Articolo principale
Tipologia: Versione Editoriale
Dimensione 4.45 MB
Formato Adobe PDF
4.45 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/475464
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact