Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
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EnglishBackground/Aim: Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage reirradiation collecting very heterogeneous series. Case Report: A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease. Conclusion: Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option.
Cuccia, F., Mortellaro, G., Ognibene, L., Craparo, G., Lo Casto, A., & Ferrera, G. (2020). Salvage re-irradiation options in adult medulloblastoma: A case report and review of the literature. IN VIVO, 34(3), 1283-1288 [10.21873/invivo.11903].
| Data di pubblicazione: | 2020 | |
| Titolo: | Salvage re-irradiation options in adult medulloblastoma: A case report and review of the literature | |
| Autori: | ||
| Citazione: | Cuccia, F., Mortellaro, G., Ognibene, L., Craparo, G., Lo Casto, A., & Ferrera, G. (2020). Salvage re-irradiation options in adult medulloblastoma: A case report and review of the literature. IN VIVO, 34(3), 1283-1288 [10.21873/invivo.11903]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.21873/invivo.11903 | |
| Abstract: | Background/Aim: Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage reirradiation collecting very heterogeneous series. Case Report: A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease. Conclusion: Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option. | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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