Background/Aim: Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage reirradiation collecting very heterogeneous series. Case Report: A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease. Conclusion: Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option.

Cuccia, F., Mortellaro, G., Ognibene, L., Craparo, G., Lo Casto, A., Ferrera, G. (2020). Salvage re-irradiation options in adult medulloblastoma: A case report and review of the literature. IN VIVO, 34(3), 1283-1288 [10.21873/invivo.11903].

Salvage re-irradiation options in adult medulloblastoma: A case report and review of the literature

Craparo, G;Lo Casto, A;Ferrera, G
2020-01-01

Abstract

Background/Aim: Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage reirradiation collecting very heterogeneous series. Case Report: A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease. Conclusion: Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option.
Cuccia, F., Mortellaro, G., Ognibene, L., Craparo, G., Lo Casto, A., Ferrera, G. (2020). Salvage re-irradiation options in adult medulloblastoma: A case report and review of the literature. IN VIVO, 34(3), 1283-1288 [10.21873/invivo.11903].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/472139
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