Microscopic foci of prostatitis may induce prostate-specific antigen (PSA) increase. PSA reduction after antibiotics might identify those patients in whom biopsy can be avoided. Ninety-nine patients received ciprofloxacin for 3 weeks, of whom 59 showed PSA reduction. Histology detected small foci of prostatitis in 65% of cases. Carcinoma was found in 40 and 20.3% of patients with unchanged or decreased PSA, respectively (P=0.03). No cancer was detected if PSA decreased below 4 ng/ml or more than 70%. Biopsy can be postponed, with a low risk of missing a cancer, if PSA decreases more than 70% or below 4 ng/ml.

SERRETTA, V., CATANESE, A., DARICELLO, G., LIOTTA, R., ALLEGRO, R., MARTORANA, A., et al. (2008). PSA reduction (after antibiotics) permits to avoid or postpone prostate biopsy in selected patients. PROSTATE CANCER AND PROSTATIC DISEASES, 11(11), 148-152 [10.1038/sj.pcan.4500996].

PSA reduction (after antibiotics) permits to avoid or postpone prostate biopsy in selected patients

SERRETTA, Vincenzo;CATANESE, Angela;LIOTTA, Raimondo;ALLEGRO, Rosalinda;MARTORANA, Anna;MELLONI, Darvinio
2008

Abstract

Microscopic foci of prostatitis may induce prostate-specific antigen (PSA) increase. PSA reduction after antibiotics might identify those patients in whom biopsy can be avoided. Ninety-nine patients received ciprofloxacin for 3 weeks, of whom 59 showed PSA reduction. Histology detected small foci of prostatitis in 65% of cases. Carcinoma was found in 40 and 20.3% of patients with unchanged or decreased PSA, respectively (P=0.03). No cancer was detected if PSA decreased below 4 ng/ml or more than 70%. Biopsy can be postponed, with a low risk of missing a cancer, if PSA decreases more than 70% or below 4 ng/ml.
Settore MED/24 - Urologia
SERRETTA, V., CATANESE, A., DARICELLO, G., LIOTTA, R., ALLEGRO, R., MARTORANA, A., et al. (2008). PSA reduction (after antibiotics) permits to avoid or postpone prostate biopsy in selected patients. PROSTATE CANCER AND PROSTATIC DISEASES, 11(11), 148-152 [10.1038/sj.pcan.4500996].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/47165
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