Prostate cancer remains a major health concern for the male population throughout the Western world. It is today widely accepted that inflammation has a role in many human cancers. In fact, inflammation is thought to incite carcinogenesis by causing cell and genome damage, promoting cellular turnover and creating a tissue microenvironment that can enhance cell replication, anglogenesis and tissue repair. Accordingly, there is a body of literature suggesting a link between chronic inflammation and prostate cancer, in which prostate inflammation may contribute to the promotion of prostate cancer development. On the other hand, high levels of endogenous gonadal steroids are considered as risk factors for prostate cancer. Interestingly, it is clear that elevation of estrogens in the presence of testosterone results in a prostate-specific Inflammatory response. Thus, it is possible that early inflammatory events stimulated by sex hormones serve as a prerequisite for the onset of prostate cancer.

Vasto, S., Carruba, G, C., Italiano, E., Di Bona, D., & Caruso, C. (2008). Inflammation and prostate cancer. FUTURE ONCOLOGY, 4(5), 637-645 [10.2217/14796694.4.5.637].

Inflammation and prostate cancer

VASTO, Sonya
Writing – Review & Editing
;
CANDORE, Giuseppina
Writing – Original Draft Preparation
;
DI BONA, Danilo
Writing – Original Draft Preparation
;
CARUSO, Calogero
Writing – Review & Editing
2008

Abstract

Prostate cancer remains a major health concern for the male population throughout the Western world. It is today widely accepted that inflammation has a role in many human cancers. In fact, inflammation is thought to incite carcinogenesis by causing cell and genome damage, promoting cellular turnover and creating a tissue microenvironment that can enhance cell replication, anglogenesis and tissue repair. Accordingly, there is a body of literature suggesting a link between chronic inflammation and prostate cancer, in which prostate inflammation may contribute to the promotion of prostate cancer development. On the other hand, high levels of endogenous gonadal steroids are considered as risk factors for prostate cancer. Interestingly, it is clear that elevation of estrogens in the presence of testosterone results in a prostate-specific Inflammatory response. Thus, it is possible that early inflammatory events stimulated by sex hormones serve as a prerequisite for the onset of prostate cancer.
Settore MED/04 - Patologia Generale
Vasto, S., Carruba, G, C., Italiano, E., Di Bona, D., & Caruso, C. (2008). Inflammation and prostate cancer. FUTURE ONCOLOGY, 4(5), 637-645 [10.2217/14796694.4.5.637].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/46640
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