Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western society mainly accounts for clinical dementia. AD has been linked to inflammation and metal biological pathway. Neuro-pathological hallmarks are senile plaques, resulting from the accumulation of several proteins and an inflammatory reaction around deposits of amyloid, a fibrillar protein,Aβ, product of cleavage of amuchlarger protein, the β-amyloid precursor protein (APP) and neurofibrillary tangles. Amyloid deposition, due to the accumulation of Aβ peptide, is the main pathogenetic mechanism. Inflammation clearly occurs in pathologically vulnerable regions of AD and several inflammatory factors influencing AD development, i.e. environmental factors (pro-inflammatory phenotype) and/ or genetic factors (pro-inflammatory genotype) have been described. At the biochemical level metals such as zinc are known to accelerate the aggregation of theamyloid peptide and play a role in the control of inflammatory responses. In particular, zinc availability may regulate mRNA cytokine expression, so influencing inflammatory network phenotypic expression.

VASTO, S., CANDORE, G., LISTÌ, F., BALISTRERI, C.R., COLONNA-ROMANO, G., MALAVOLTA, M., et al. (2008). Inflammation, genes and zinc in Alzheimer's disease. BRAIN RESEARCH REVIEWS, 58, 96-105 [10.1016/j.brainresrev.2007.12.001].

Inflammation, genes and zinc in Alzheimer's disease.

VASTO, Sonya;CANDORE, Giuseppina;LISTI', Florinda;BALISTRERI, Carmela Rita;COLONNA ROMANO, Giuseppina;LIO, Domenico;NUZZO, Domenico;CARUSO, Calogero
2008-01-01

Abstract

Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western society mainly accounts for clinical dementia. AD has been linked to inflammation and metal biological pathway. Neuro-pathological hallmarks are senile plaques, resulting from the accumulation of several proteins and an inflammatory reaction around deposits of amyloid, a fibrillar protein,Aβ, product of cleavage of amuchlarger protein, the β-amyloid precursor protein (APP) and neurofibrillary tangles. Amyloid deposition, due to the accumulation of Aβ peptide, is the main pathogenetic mechanism. Inflammation clearly occurs in pathologically vulnerable regions of AD and several inflammatory factors influencing AD development, i.e. environmental factors (pro-inflammatory phenotype) and/ or genetic factors (pro-inflammatory genotype) have been described. At the biochemical level metals such as zinc are known to accelerate the aggregation of theamyloid peptide and play a role in the control of inflammatory responses. In particular, zinc availability may regulate mRNA cytokine expression, so influencing inflammatory network phenotypic expression.
2008
Settore MED/04 - Patologia Generale
VASTO, S., CANDORE, G., LISTÌ, F., BALISTRERI, C.R., COLONNA-ROMANO, G., MALAVOLTA, M., et al. (2008). Inflammation, genes and zinc in Alzheimer's disease. BRAIN RESEARCH REVIEWS, 58, 96-105 [10.1016/j.brainresrev.2007.12.001].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/46636
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