Innate immunity provides a first line of host defense against infection by recognizing and killing microbes while simultaneously activating an instructive immune response. Toll-like receptors (TLRs) are principal mediators of rapid microbial recognition and function mainly by detection of pathogen-associated molecular patterns that do not exist in the host. Recognition of their ligands leads to a series of signaling events resulting in acute host responses, involved in killing pathogens. Discussion We describe the involvement of TLR4 polymorphisms in ageing, and in particular in age-related diseases, suggesting the crucial role of molecules of innate immunity in pathophysiology of these diseases. Hence, we observed that pro-inflammatory alleles may be related to unsuccessful ageing, such as Alzheimer’s disease, prostate cancer, and atherosclerosis; in contrast, the control of inflammation by anti-inflammatory alleles may result in increased longevity and successful ageing. Finally, a possible therapeutic approach to delay age-related diseases is outlined.

BALISTRERI CR, COLONNA-ROMANO G, LIO D, CANDORE G, CARUSO C (2009). TLR4 POLYMORPHISMS AND AGEING: IMPLICATIONS FOR THE PATHOPHYSIOLOGY OF AGE-RELATED DISEASES. JOURNAL OF CLINICAL IMMUNOLOGY, 29, 406-415 [10.1007/s10875-009-9297-5].

TLR4 POLYMORPHISMS AND AGEING: IMPLICATIONS FOR THE PATHOPHYSIOLOGY OF AGE-RELATED DISEASES

BALISTRERI, Carmela Rita;COLONNA ROMANO, Giuseppina;LIO, Domenico;CANDORE, Giuseppina;CARUSO, Calogero
2009-01-01

Abstract

Innate immunity provides a first line of host defense against infection by recognizing and killing microbes while simultaneously activating an instructive immune response. Toll-like receptors (TLRs) are principal mediators of rapid microbial recognition and function mainly by detection of pathogen-associated molecular patterns that do not exist in the host. Recognition of their ligands leads to a series of signaling events resulting in acute host responses, involved in killing pathogens. Discussion We describe the involvement of TLR4 polymorphisms in ageing, and in particular in age-related diseases, suggesting the crucial role of molecules of innate immunity in pathophysiology of these diseases. Hence, we observed that pro-inflammatory alleles may be related to unsuccessful ageing, such as Alzheimer’s disease, prostate cancer, and atherosclerosis; in contrast, the control of inflammation by anti-inflammatory alleles may result in increased longevity and successful ageing. Finally, a possible therapeutic approach to delay age-related diseases is outlined.
2009
Settore MED/04 - Patologia Generale
BALISTRERI CR, COLONNA-ROMANO G, LIO D, CANDORE G, CARUSO C (2009). TLR4 POLYMORPHISMS AND AGEING: IMPLICATIONS FOR THE PATHOPHYSIOLOGY OF AGE-RELATED DISEASES. JOURNAL OF CLINICAL IMMUNOLOGY, 29, 406-415 [10.1007/s10875-009-9297-5].
File in questo prodotto:
File Dimensione Formato  
JCI.pdf

Solo gestori archvio

Descrizione: Articolo principale
Dimensione 330.53 kB
Formato Adobe PDF
330.53 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/46609
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 110
  • ???jsp.display-item.citation.isi??? 99
social impact