Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies

Collantoni, E; Solmi, M; Gallicchio, D; Santonastaso, P; Meneguzzo, P; Carvalho, AF; Stubbs, B; Clementi, M; Pinato, C; Forzan, M; Cassina, M; Fontana, F; Piva, I; Siani, R; Salvo, P; Tenconi, E; Veronese, N; Correll, CU; Favaro, A

doi:10.1002/erv.2555

Objectives: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). Methods: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian ‘Biobanca Veneta per i Disturbi Alimentari’ biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. Results: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96–1.04, p-values: 0.46–0.97, I2 = 0%] and when analysing separately patients with AN (ORs: 0.94–1.04, p-values: 0.31–0.61, I2 = 0%) or BN (ORs: 0.80–1.09, p-values: 0.28–0.64, I2 = 0–44%). Conclusions: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

Collantoni, E., Solmi, M., Gallicchio, D., Santonastaso, P., Meneguzzo, P., Carvalho, A., et al. (2017). Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies. EUROPEAN EATING DISORDERS REVIEW, 25(6), 524-532.

Data di pubblicazione:	2017
Titolo:	Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies
Autori:	Collantoni, E. (Corresponding) Solmi, M. Gallicchio, D. Santonastaso, P. Meneguzzo, P. Carvalho, A. F. Stubbs, B. Clementi, M. Pinato, C. Forzan, M. Cassina, M. Fontana, F. Piva, I. Siani, R. Salvo, P. Tenconi, E. Veronese, Nicola Correll, C. U. Favaro, A. mostra contributor esterni nascondi contributor esterni
Citazione:	Collantoni, E., Solmi, M., Gallicchio, D., Santonastaso, P., Meneguzzo, P., Carvalho, A., et al. (2017). Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies. EUROPEAN EATING DISORDERS REVIEW, 25(6), 524-532.
Rivista:	EUROPEAN EATING DISORDERS REVIEW
Digital Object Identifier (DOI):	http://dx.doi.org/10.1002/erv.2555
Abstract:	Objectives: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). Methods: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian ‘Biobanca Veneta per i Disturbi Alimentari’ biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. Results: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96–1.04, p-values: 0.46–0.97, I2 = 0%] and when analysing separately patients with AN (ORs: 0.94–1.04, p-values: 0.31–0.61, I2 = 0%) or BN (ORs: 0.80–1.09, p-values: 0.28–0.64, I2 = 0–44%). Conclusions: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
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