Background A possible relationship between mitochondrial haplogroups and psychiatric diseases (e.g. schizophrenia and bipolar disorder) has been postulated, but data regarding depression is still limited. We investigated whether any mitochondrial haplogroup carried a significant higher risk of depressive symptoms in a large prospective cohort of North American people included in the Osteoarthritis Initiative. Methods Cross sectional data was derived from the Osteoarthritis Initiative. The haplogroup was assigned through a combination of sequencing and PCR-RFLP techniques. All the mitochondrial haplogroups were named following this nomenclature: H, U, K, J, T, V, SuperHV, I, W, X or Others. Depression was ascertained through the 20-item Center for Epidemiologic Studies-Depression (CES-D), with ≥16 indicating depressive symptoms. Results Overall, 3601 Caucasian participants (55.9% women), mean age of 61.7±9.3 years were included. No difference was observed in mitochondrial haplogroups frequency among those with depressive symptoms (n=285, =7.9% of the baseline population) compared to participants with no depressive symptoms (N=3316) (chi-square test=0.53). Using a logistic regression analysis, adjusted for eight potential confounders, with those having the haplogroup H as the reference group (the most common haplogroup), no significant mitochondrial haplogroup was associated with prevalent depressive symptoms. The same results were evident in secondary analysis in which we matched depressed and non-depressed participants for age and sex. Limitations Cross-sectional design; only CES-D for evaluating mood; participants not totally representative of general population. Conclusions We found no evidence of any relationship between specific mitochondrial haplogroups and depressive symptoms. Future longitudinal research is required to confirm/ refute these findings. © 2017 Elsevier B.V.

Veronese, N., Stubbs, B., Solmi, M., Vaona, A., Demurtas, J., Carvalho, A., et al. (2017). Mitochondrial genetic haplogroups and depressive symptoms: A large study among people in North America. JOURNAL OF AFFECTIVE DISORDERS, 217, 55-59 [10.1016/j.jad.2017.03.069].

Mitochondrial genetic haplogroups and depressive symptoms: A large study among people in North America

Veronese, N.
;
2017-01-01

Abstract

Background A possible relationship between mitochondrial haplogroups and psychiatric diseases (e.g. schizophrenia and bipolar disorder) has been postulated, but data regarding depression is still limited. We investigated whether any mitochondrial haplogroup carried a significant higher risk of depressive symptoms in a large prospective cohort of North American people included in the Osteoarthritis Initiative. Methods Cross sectional data was derived from the Osteoarthritis Initiative. The haplogroup was assigned through a combination of sequencing and PCR-RFLP techniques. All the mitochondrial haplogroups were named following this nomenclature: H, U, K, J, T, V, SuperHV, I, W, X or Others. Depression was ascertained through the 20-item Center for Epidemiologic Studies-Depression (CES-D), with ≥16 indicating depressive symptoms. Results Overall, 3601 Caucasian participants (55.9% women), mean age of 61.7±9.3 years were included. No difference was observed in mitochondrial haplogroups frequency among those with depressive symptoms (n=285, =7.9% of the baseline population) compared to participants with no depressive symptoms (N=3316) (chi-square test=0.53). Using a logistic regression analysis, adjusted for eight potential confounders, with those having the haplogroup H as the reference group (the most common haplogroup), no significant mitochondrial haplogroup was associated with prevalent depressive symptoms. The same results were evident in secondary analysis in which we matched depressed and non-depressed participants for age and sex. Limitations Cross-sectional design; only CES-D for evaluating mood; participants not totally representative of general population. Conclusions We found no evidence of any relationship between specific mitochondrial haplogroups and depressive symptoms. Future longitudinal research is required to confirm/ refute these findings. © 2017 Elsevier B.V.
2017
Veronese, N., Stubbs, B., Solmi, M., Vaona, A., Demurtas, J., Carvalho, A., et al. (2017). Mitochondrial genetic haplogroups and depressive symptoms: A large study among people in North America. JOURNAL OF AFFECTIVE DISORDERS, 217, 55-59 [10.1016/j.jad.2017.03.069].
File in questo prodotto:
File Dimensione Formato  
nihms868675.pdf

Solo gestori archvio

Tipologia: Post-print
Dimensione 367.01 kB
Formato Adobe PDF
367.01 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
1-s2.0-S016503271730215X-main.pdf

Solo gestori archvio

Tipologia: Versione Editoriale
Dimensione 383.48 kB
Formato Adobe PDF
383.48 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/460467
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact