Low serum levels of 25 hydroxyvitamin D (25OHD) (hypovitaminosis D) is common in older adults and associated with several negative outcomes. The association between hypovitaminosis D and diabetes in older adults is equivocal, however. We conducted a meta-analysis investigating if hypovitaminosis D is associated with diabetes in prospective studies among older participants. Two investigators systematically searched major electronic databases, from inception until 10/07/2016. The cumulative incidence of diabetes among groups was estimated according to baseline serum 25OHD levels. Random effect models were used to assess the association between hypovitaminosis D and diabetes at follow-up. From 4268 non-duplicate hits, 9 studies were included; these followed 28,258 participants with a mean age of 67.7 years for a median of 7.7 years. Compared with higher levels of 25OHD, lower levels of 25OHD were associated with a higher risk of developing diabetes (6 studies; n = 13,563; RR = 1.31; 95% CI: 1.11–1.54; I2 = 37%). The findings remained significant after adjusting for a median of 11 potential confounders in all the studies available (9 studies; n = 28,258; RR = 1.17; 95% CI: 1.03–1.33; p = 0.02; I2 = 0%). In conclusion, our data suggest that hypovitaminosis D is associated with an elevated risk of future diabetes in older people. Future longitudinal studies are required and should seek to confirm these findings and explore potential pathophysiological underpinnings. © 2017 Elsevier B.V.

Lucato, P., Solmi, M., Maggi, S., Bertocco, A., Bano, G., Trevisan, C., et al. (2017). Low vitamin D levels increase the risk of type 2 diabetes in older adults: A systematic review and meta-analysis [10.1016/j.maturitas.2017.02.016].

Low vitamin D levels increase the risk of type 2 diabetes in older adults: A systematic review and meta-analysis

Veronese, N.;
2017-01-01

Abstract

Low serum levels of 25 hydroxyvitamin D (25OHD) (hypovitaminosis D) is common in older adults and associated with several negative outcomes. The association between hypovitaminosis D and diabetes in older adults is equivocal, however. We conducted a meta-analysis investigating if hypovitaminosis D is associated with diabetes in prospective studies among older participants. Two investigators systematically searched major electronic databases, from inception until 10/07/2016. The cumulative incidence of diabetes among groups was estimated according to baseline serum 25OHD levels. Random effect models were used to assess the association between hypovitaminosis D and diabetes at follow-up. From 4268 non-duplicate hits, 9 studies were included; these followed 28,258 participants with a mean age of 67.7 years for a median of 7.7 years. Compared with higher levels of 25OHD, lower levels of 25OHD were associated with a higher risk of developing diabetes (6 studies; n = 13,563; RR = 1.31; 95% CI: 1.11–1.54; I2 = 37%). The findings remained significant after adjusting for a median of 11 potential confounders in all the studies available (9 studies; n = 28,258; RR = 1.17; 95% CI: 1.03–1.33; p = 0.02; I2 = 0%). In conclusion, our data suggest that hypovitaminosis D is associated with an elevated risk of future diabetes in older people. Future longitudinal studies are required and should seek to confirm these findings and explore potential pathophysiological underpinnings. © 2017 Elsevier B.V.
Lucato, P., Solmi, M., Maggi, S., Bertocco, A., Bano, G., Trevisan, C., et al. (2017). Low vitamin D levels increase the risk of type 2 diabetes in older adults: A systematic review and meta-analysis [10.1016/j.maturitas.2017.02.016].
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0378512216303255-main.pdf

Solo gestori archvio

Tipologia: Versione Editoriale
Dimensione 739.69 kB
Formato Adobe PDF
739.69 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/460346
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 59
  • ???jsp.display-item.citation.isi??? 54
social impact