Background: osteoarthritis (OA) is associated with a number of medical morbidities. Although the prevalence of depression and depressive symptoms is presumed to be high in people with OA, no prospective comparative study has analyzed its incidence. Objective: to determine whether OA was associated with an increased odds of developing depressive symptoms. Design: longitudinal cohort study (follow-up: 4.2 years). Setting: data were gathered from the North American Osteoarthritis Initiative (OAI) dataset. Subjects: people at higher risk developing OA. Methods: OA diagnosis was defined as the presence of OA at hand, knee, hip, back/neck or other sites at baseline. Depressive symptoms were defined using the 20-item Center for Epidemiologic Studies-Depression (cut-off 16 points) after 4 years. Results: a total of 3,491 people without depressive symptoms at baseline were analyzed (1,506 with OA/1,985 without). Using an adjusted logistic regression analysis for 12 potential confounders, people with OA had a similar odds of depressive symptoms at follow-up compared to those without OA (odds ratio (OR): 1.26; 95% confidence of interval (CI): 0.95-1.67). However, multi-site OA (i.e. OA ≥ 2 sites; OR: 1.48, 95% CI: 1.07-2.05) and the specific presence of hip (OR: 1.72; 95% CI: 1.08-2.73) or knee OA (OR: 1.43; 95% CI: 1.03-1.98) were associated with a greater odds of developing depressive symptoms compared to people without OA. Conclusions: this is the first study of longitudinal data to demonstrate people with multi-site, hip or knee OA have a greater odds of developing depressive symptoms compared to people without OA. This suggests that OA may be associated with future mental health burden. © The Author 2016.

Veronese, N., Stubbs, B., Solmi, M., Smith, T., Noale, M., Cooper, C., et al. (2017). Association between lower limb osteoarthritis and incidence of depressive symptoms: Data from the osteoarthritis initiative. AGE AND AGEING, 46(3), 470-476 [10.1093/ageing/afw216].

Association between lower limb osteoarthritis and incidence of depressive symptoms: Data from the osteoarthritis initiative

Veronese, N.
;
2017-01-01

Abstract

Background: osteoarthritis (OA) is associated with a number of medical morbidities. Although the prevalence of depression and depressive symptoms is presumed to be high in people with OA, no prospective comparative study has analyzed its incidence. Objective: to determine whether OA was associated with an increased odds of developing depressive symptoms. Design: longitudinal cohort study (follow-up: 4.2 years). Setting: data were gathered from the North American Osteoarthritis Initiative (OAI) dataset. Subjects: people at higher risk developing OA. Methods: OA diagnosis was defined as the presence of OA at hand, knee, hip, back/neck or other sites at baseline. Depressive symptoms were defined using the 20-item Center for Epidemiologic Studies-Depression (cut-off 16 points) after 4 years. Results: a total of 3,491 people without depressive symptoms at baseline were analyzed (1,506 with OA/1,985 without). Using an adjusted logistic regression analysis for 12 potential confounders, people with OA had a similar odds of depressive symptoms at follow-up compared to those without OA (odds ratio (OR): 1.26; 95% confidence of interval (CI): 0.95-1.67). However, multi-site OA (i.e. OA ≥ 2 sites; OR: 1.48, 95% CI: 1.07-2.05) and the specific presence of hip (OR: 1.72; 95% CI: 1.08-2.73) or knee OA (OR: 1.43; 95% CI: 1.03-1.98) were associated with a greater odds of developing depressive symptoms compared to people without OA. Conclusions: this is the first study of longitudinal data to demonstrate people with multi-site, hip or knee OA have a greater odds of developing depressive symptoms compared to people without OA. This suggests that OA may be associated with future mental health burden. © The Author 2016.
Veronese, N., Stubbs, B., Solmi, M., Smith, T., Noale, M., Cooper, C., et al. (2017). Association between lower limb osteoarthritis and incidence of depressive symptoms: Data from the osteoarthritis initiative. AGE AND AGEING, 46(3), 470-476 [10.1093/ageing/afw216].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/459545
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