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EnglishBackground: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health. © 2018 Bentham Science Publishers.
Fusaro, M., Gallieni, M., Aghi, A., Iervasi, G., Rizzo, M., Stucchi, A., et al. (2018). Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients. CURRENT VASCULAR PHARMACOLOGY, 16(6), 603-609.
| Data di pubblicazione: | 2018 | |
| Titolo: | Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients | |
| Autori: | ||
| Citazione: | Fusaro, M., Gallieni, M., Aghi, A., Iervasi, G., Rizzo, M., Stucchi, A., et al. (2018). Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients. CURRENT VASCULAR PHARMACOLOGY, 16(6), 603-609. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.2174/1570161115666170919182421 | |
| Abstract: | Background: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health. © 2018 Bentham Science Publishers. | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/10447/454620
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