Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
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EnglishThe aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. A systematic search of the literature across nine databases was conducted from inception until 15th March 2020, following the PRISMA guidelines. Patients with a validated diagnosis of COVID-19 and using corticosteroids were included, considering all health outcomes. Four studies with 542 Chinese participants were included. Two studies reported negative findings regarding the use of corticosteroids in patients with COVID-19, i.e., corticosteroids had a detrimental impact on clinical outcomes. One study reported no significant association between the use of corticosteroids and clinical outcomes. However, one study, on 201 participants with different stages of pneumonia due to COVID-19, found that in more severe forms, the administration of methylprednisolone significantly reduced the risk of death by 62%. The literature to date does not fully support the routine use of corticosteroids in COVID-19, but some findings suggest that methylprednisolone could lower mortality rate in more severe forms of the condition. © 2020 Veronese, Demurtas, Yang, Tonelli, Barbagallo, Lopalco, Lagolio, Celotto, Pizzol, Zou, Tully, Ilie, Trott, López-Sánchez and Smith.
Veronese, N., Demurtas, J., Yang, L., Tonelli, R., Barbagallo, M., Lopalco, P., et al. (2020). Use of corticosteroids in Coronavirus disease 2019 pneumonia: A systematic review of the literature.
| Data di pubblicazione: | 2020 |
| Titolo: | Use of corticosteroids in Coronavirus disease 2019 pneumonia: A systematic review of the literature |
| Autori: | |
| Citazione: | Veronese, N., Demurtas, J., Yang, L., Tonelli, R., Barbagallo, M., Lopalco, P., et al. (2020). Use of corticosteroids in Coronavirus disease 2019 pneumonia: A systematic review of the literature. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3389/fmed.2020.00170 |
| Abstract: | The aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. A systematic search of the literature across nine databases was conducted from inception until 15th March 2020, following the PRISMA guidelines. Patients with a validated diagnosis of COVID-19 and using corticosteroids were included, considering all health outcomes. Four studies with 542 Chinese participants were included. Two studies reported negative findings regarding the use of corticosteroids in patients with COVID-19, i.e., corticosteroids had a detrimental impact on clinical outcomes. One study reported no significant association between the use of corticosteroids and clinical outcomes. However, one study, on 201 participants with different stages of pneumonia due to COVID-19, found that in more severe forms, the administration of methylprednisolone significantly reduced the risk of death by 62%. The literature to date does not fully support the routine use of corticosteroids in COVID-19, but some findings suggest that methylprednisolone could lower mortality rate in more severe forms of the condition. © 2020 Veronese, Demurtas, Yang, Tonelli, Barbagallo, Lopalco, Lagolio, Celotto, Pizzol, Zou, Tully, Ilie, Trott, López-Sánchez and Smith. |
| Appare nelle tipologie: | 1.09 Review essay (rassegna critica) |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| fmed-07-00170.pdf | Versione Editoriale | Open Access Visualizza/Apri |
http://hdl.handle.net/10447/454114
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