Histone deacetylases (HDACs) are key components of the epigenetic machinery controlling gene expression. They are involved in chromatin remodeling events via post-translational histone modifications but may also act on nonhistone proteins, influencing many fundamental cellular processes. Due to the key involvement of HDACs in serious human pathologies, including cancer, HDAC inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of secondary metabolites showing active pharmacological properties and an extensive spectrum of biomedical applications. Some of these compounds possess HDACi properties.

Luparello C, Vazzana M (2020). Histone Deacetylase Inhibitors. In Encyclopedia platform (pp. 1-12).

Histone Deacetylase Inhibitors

Luparello C
;
Vazzana M
2020

Abstract

Histone deacetylases (HDACs) are key components of the epigenetic machinery controlling gene expression. They are involved in chromatin remodeling events via post-translational histone modifications but may also act on nonhistone proteins, influencing many fundamental cellular processes. Due to the key involvement of HDACs in serious human pathologies, including cancer, HDAC inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of secondary metabolites showing active pharmacological properties and an extensive spectrum of biomedical applications. Some of these compounds possess HDACi properties.
histone deacetylase inhibitors; marine invertebrates; anticancer compounds; biomedical applications; Porifera; Cnidaria; Echinodermata
Luparello C, Vazzana M (2020). Histone Deacetylase Inhibitors. In Encyclopedia platform (pp. 1-12).
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/450683
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