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EnglishReactivation of hepatitis B virus infection in subjects receiving cytotoxic treatment for heamatological malignancies occurs in 21–53% of chronic HBsAg carriers and in an unknown number of HBsAg negative subjects harbouring occult HBV infection. Immmunotherapy with alemtuzumab, a humanized monoclonal antibody against CD52 epitopes on lymphocytes cells produces deep immunosuppression. We describe two subjects with chronic lymphocytic leukaemia and occult HBV infection who developed a virological and biochemical flare of hepatitis B following immunotherapy with alemtuzumab. One of them developed full blown hepatitis with seroreversion from anti-HBs to HBsAg after four weeks of alemtuzumab therapy. Lamivudine (100 mg die) achieved a complete clinical recovery and HBV-DNA clearance from blood within 8 weeks. The second patient (HBsAg and HBV-DNA seronegative, anti-HBs and anti-HBc positive before treatment) was kept under prophylaxis with lamivudine up to three months after alemtuzumab. Two months after withdrawal of lamivudine, clinical and laboratory features of acute hepatitis B developed. Lamivudine therapy was restarted and a prompt recovery was obtained with HBsAg and HBV-DNA clearance.
Iannitto, E., Minardi, V., Calvaruso, G., Mule', A., Ammatuna, E., Trapani, R., et al. (2005). Hepatitis B virus reactivation and alemtuzumab therapy. EUROPEAN JOURNAL OF HAEMATOLOGY, 74, 254-258 [10.1111/j.1600-0609.2004.00375.x].
| Data di pubblicazione: | 2005 | |
| Titolo: | Hepatitis B virus reactivation and alemtuzumab therapy | |
| Autori: | ||
| Citazione: | Iannitto, E., Minardi, V., Calvaruso, G., Mule', A., Ammatuna, E., Trapani, R., et al. (2005). Hepatitis B virus reactivation and alemtuzumab therapy. EUROPEAN JOURNAL OF HAEMATOLOGY, 74, 254-258 [10.1111/j.1600-0609.2004.00375.x]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1600-0609.2004.00375.x | |
| Abstract: | Reactivation of hepatitis B virus infection in subjects receiving cytotoxic treatment for heamatological malignancies occurs in 21–53% of chronic HBsAg carriers and in an unknown number of HBsAg negative subjects harbouring occult HBV infection. Immmunotherapy with alemtuzumab, a humanized monoclonal antibody against CD52 epitopes on lymphocytes cells produces deep immunosuppression. We describe two subjects with chronic lymphocytic leukaemia and occult HBV infection who developed a virological and biochemical flare of hepatitis B following immunotherapy with alemtuzumab. One of them developed full blown hepatitis with seroreversion from anti-HBs to HBsAg after four weeks of alemtuzumab therapy. Lamivudine (100 mg die) achieved a complete clinical recovery and HBV-DNA clearance from blood within 8 weeks. The second patient (HBsAg and HBV-DNA seronegative, anti-HBs and anti-HBc positive before treatment) was kept under prophylaxis with lamivudine up to three months after alemtuzumab. Two months after withdrawal of lamivudine, clinical and laboratory features of acute hepatitis B developed. Lamivudine therapy was restarted and a prompt recovery was obtained with HBsAg and HBV-DNA clearance. | |
| Settore Scientifico Disciplinare: | Settore MED/07 - Microbiologia E Microbiologia Clinica Settore MED/12 - Gastroenterologia Settore MED/15 - Malattie Del Sangue | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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