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EnglishIn the last years, numerous studies have supported the idea that, at least in part, motivational and neuropharmacological effects of ethanol are mediated by its first brain-derived metabolite, acetaldehyde, and its bioderivate salsolinol. This review aims at gathering and shaping as a whole the evidence on their role in the mechanism of action of ethanol. Acetaldehyde and salsolinol interact with the reward brain system and are involved as primum movens of motivational and addictive behaviour that can be especially relevant to ethanol use disorders. Understanding the neurobiology of acetaldehyde and salsolinol holds promising potential for the development of novel pharmacological approaches for reducing ethanol abuse.
Cavallaro A., Lavanco G., Giammanco M., & Cannizzaro E. (2017). Acetaldehyde and salsolinol in ethanol's two-step mechanism of action: An overview. JOURNAL OF BIOLOGICAL RESEARCH, 90(2), 109-115.
| Data di pubblicazione: | 2017 |
| Titolo: | Acetaldehyde and salsolinol in ethanol's two-step mechanism of action: An overview |
| Autori: | |
| Citazione: | Cavallaro A., Lavanco G., Giammanco M., & Cannizzaro E. (2017). Acetaldehyde and salsolinol in ethanol's two-step mechanism of action: An overview. JOURNAL OF BIOLOGICAL RESEARCH, 90(2), 109-115. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.4081/jbr.2017.6751 |
| Abstract: | In the last years, numerous studies have supported the idea that, at least in part, motivational and neuropharmacological effects of ethanol are mediated by its first brain-derived metabolite, acetaldehyde, and its bioderivate salsolinol. This review aims at gathering and shaping as a whole the evidence on their role in the mechanism of action of ethanol. Acetaldehyde and salsolinol interact with the reward brain system and are involved as primum movens of motivational and addictive behaviour that can be especially relevant to ethanol use disorders. Understanding the neurobiology of acetaldehyde and salsolinol holds promising potential for the development of novel pharmacological approaches for reducing ethanol abuse. |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Acetaldehyde_and_salsolinol__2017 (1).pdf | Versione Editoriale | Open Access Visualizza/Apri |
http://hdl.handle.net/10447/442538
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