INTRODUCTION: Visceral leishmaniasis is a potentially life-threatening infectious disease which is caused by parasites of the genus Leishmania and characterized in most cases by the presence of fever as well as signs and symptoms similar to those found in liver cirrhosis. CASE PRESENTATION: In this case report we describe the history of a 50-year-old Caucasian man incorrectly diagnosed as having hepatitis C virus-associated liver cirrhosis, with a massive weight loss of around 100 kg during the previous 2 years. However, suspecting a lymphoproliferative disorder, we were able to make a correct diagnosis of visceral leishmaniasis by bone marrow examination. After a course of therapy with Liposomal Amphotericin-B the patient recovered and now, 20 months post-treatment, he is well and has regained a good part of the lost weight. CONCLUSIONS: This case taught us that patients with massive splenomegaly, even with a diagnosis of liver cirrhosis, should be investigated for infectious or lymphoproliferative diseases.

Giannitrapani, L., Soresi, M., La Spada, E., Tripodo, C., Montalto, G. (2009). Progressive visceral leishmaniasis misdiagnosed as cirrhosis of the liver: a case report. JOURNAL OF MEDICAL CASE REPORTS, 25(3), 7265.

Progressive visceral leishmaniasis misdiagnosed as cirrhosis of the liver: a case report.

GIANNITRAPANI, Lydia;SORESI, Maurizio;LA SPADA, Emanuele;TRIPODO, Claudio;MONTALTO, Giuseppe
2009-01-01

Abstract

INTRODUCTION: Visceral leishmaniasis is a potentially life-threatening infectious disease which is caused by parasites of the genus Leishmania and characterized in most cases by the presence of fever as well as signs and symptoms similar to those found in liver cirrhosis. CASE PRESENTATION: In this case report we describe the history of a 50-year-old Caucasian man incorrectly diagnosed as having hepatitis C virus-associated liver cirrhosis, with a massive weight loss of around 100 kg during the previous 2 years. However, suspecting a lymphoproliferative disorder, we were able to make a correct diagnosis of visceral leishmaniasis by bone marrow examination. After a course of therapy with Liposomal Amphotericin-B the patient recovered and now, 20 months post-treatment, he is well and has regained a good part of the lost weight. CONCLUSIONS: This case taught us that patients with massive splenomegaly, even with a diagnosis of liver cirrhosis, should be investigated for infectious or lymphoproliferative diseases.
2009
Giannitrapani, L., Soresi, M., La Spada, E., Tripodo, C., Montalto, G. (2009). Progressive visceral leishmaniasis misdiagnosed as cirrhosis of the liver: a case report. JOURNAL OF MEDICAL CASE REPORTS, 25(3), 7265.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/44084
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