Post-radiation proctitis (PRP) is one of most common complications after abdominal and pelvic radiotherapy for different malignancies. Chronic radiation proctitis (CRP) usually develops 90 days or more after radiation. The present study aimed to show the employment of Levorag Emulgel® (THD S.p.A Correggio, Reggio-Emilia, Italy) as off-label topical treatment, by instillation, to resolve the acute phase of PRP around a coloanal anastomosis, in a patient undergone surgery for an adenocarcinoma of the low rectum, then treated with the Gatekeeper® methodic to resolve fecal incontinence as consequence of the first surgical rectal resection. In conclusion, we can affirm that our methodic could represent a novelty for the new concept of evidencebased medicine. At now, standardized guidelines about the management of PRP don’t exist,5 so that the employment of THD Levorag Emulgel® by topical instillation could be a good proposal to assess a standardized protocol.
Benedetto, D.T., Carola M, G., Carlo, B., Simone, T., Bernardo, M., Mario, F., et al. (2020). ANTINFLAMMATORY EFFECT OF LEVORAG (THD) EMULGEL ON RADIATION PROCTOCOLITIS AROUND A COLO-ANAL ANASTOMOSIS: AN INNOVATIVE CASE REPORT. MINERVA CHIRURGICA, 74, 1-2 [10.23736/S0026-4733.20.08321-2].
ANTINFLAMMATORY EFFECT OF LEVORAG (THD) EMULGEL ON RADIATION PROCTOCOLITIS AROUND A COLO-ANAL ANASTOMOSIS: AN INNOVATIVE CASE REPORT
Carola M, Gagliardo
;Antonio,Ciulla;Francesco,Carini;Giovanni,TomaselloSupervision
2020-01-01
Abstract
Post-radiation proctitis (PRP) is one of most common complications after abdominal and pelvic radiotherapy for different malignancies. Chronic radiation proctitis (CRP) usually develops 90 days or more after radiation. The present study aimed to show the employment of Levorag Emulgel® (THD S.p.A Correggio, Reggio-Emilia, Italy) as off-label topical treatment, by instillation, to resolve the acute phase of PRP around a coloanal anastomosis, in a patient undergone surgery for an adenocarcinoma of the low rectum, then treated with the Gatekeeper® methodic to resolve fecal incontinence as consequence of the first surgical rectal resection. In conclusion, we can affirm that our methodic could represent a novelty for the new concept of evidencebased medicine. At now, standardized guidelines about the management of PRP don’t exist,5 so that the employment of THD Levorag Emulgel® by topical instillation could be a good proposal to assess a standardized protocol.File | Dimensione | Formato | |
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