Various derivatives of the heterocyclic system 1,12,12a,12b-tetrahydrobis-1,2,4-triazolo[4,3-a :3′,4′-c ]quinoxaline of pharmaceutical interest have been obtained by double site- and regio-selective 1,3-dipolar cycloaddition of arylnitrilimines to quinoxalines. No evidence for the formation of mono-adducts was obtained, at variance with literature reports. Specific studies to establish the exact stereochemistry of the bis-cycloadducts were undertaken.
LAURIA, A., GUARCELLO, A., DATTOLO, G., ALMERICO, A.M. (2008). Bis-1,2,4-triazolo[4,3-a:3',4'-c]quinoxalines of pharmaceutical interest from 1,3-dipolar cycloaddition. TETRAHEDRON LETTERS, 49(11), 1847-1850 [10.1016/j.tetlet.2008.01.047].
Bis-1,2,4-triazolo[4,3-a:3',4'-c]quinoxalines of pharmaceutical interest from 1,3-dipolar cycloaddition
LAURIA, Antonino;GUARCELLO, Annalisa;DATTOLO, Gaetano;ALMERICO, Anna Maria
2008-01-01
Abstract
Various derivatives of the heterocyclic system 1,12,12a,12b-tetrahydrobis-1,2,4-triazolo[4,3-a :3′,4′-c ]quinoxaline of pharmaceutical interest have been obtained by double site- and regio-selective 1,3-dipolar cycloaddition of arylnitrilimines to quinoxalines. No evidence for the formation of mono-adducts was obtained, at variance with literature reports. Specific studies to establish the exact stereochemistry of the bis-cycloadducts were undertaken.
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