A series of 2-oxo-[1,4]oxazino[3,2-e ]indoles, heteroanalogues of Angelicin, have been synthesized by a multistep sequence consisting of the annelation of the oxazine ring on the indole moiety. The phototoxicity and the antiproliferative activity of the new derivatives were investigated.
BARRAJA, P., DIANA, P., MONTALBANO, A., MARTORANA, A., CARBONE, A., CIRRINCIONE, G. (2009). Synthesis of the New Ring System 2-Oxo-[1,4]oxazino[3,2-e]indole, Heteroanalogue of Angelicin. TETRAHEDRON LETTERS, 50(28), 4182-4184 [10.1016/j.tetlet.2009.05.007].
Synthesis of the New Ring System 2-Oxo-[1,4]oxazino[3,2-e]indole, Heteroanalogue of Angelicin
BARRAJA, Paola;DIANA, Patrizia;MONTALBANO, Alessandra;MARTORANA, Annamaria;CARBONE, Anna;CIRRINCIONE, Girolamo
2009-01-01
Abstract
A series of 2-oxo-[1,4]oxazino[3,2-e ]indoles, heteroanalogues of Angelicin, have been synthesized by a multistep sequence consisting of the annelation of the oxazine ring on the indole moiety. The phototoxicity and the antiproliferative activity of the new derivatives were investigated.
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