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EnglishWe report that extracellular matrix and neurons modulate the expression of occludin, one of the main components of tight junctions, by rat brain endothelial cells (RBE4.B). Of the three extracellular matrix proteins which we tested (collagen I, collagen IV, and laminin), collagen IV stimulated at the best the expression of occludin mRNA. The corresponding protein, however, was not synthesized. Significant amounts of occludin accumulated only when RBE4.B cells were cultured on collagen IV-coated inserts, in the presence of cortical neurons, plated on laminin-coated companion wells. Finally, occludin segregated at the cell periphery, only when endothelial cells were co- cultured with neurons for ≥ 1 week. (C) 2000 Lippincott Williams and Wilkins.
Savettieri G., Di Liegro I., Catania C., Licata L., Pitarresi G.L., D'Agostino S., et al. (2000). Neurons and ECM regulate occludin localization in brain endothelial cells. NEUROREPORT, 11(5), 1081-1084.
| Data di pubblicazione: | 2000 | |
| Titolo: | Neurons and ECM regulate occludin localization in brain endothelial cells | |
| Autori: | CESTELLI, Alessandro (Corresponding) | |
| Citazione: | Savettieri G., Di Liegro I., Catania C., Licata L., Pitarresi G.L., D'Agostino S., et al. (2000). Neurons and ECM regulate occludin localization in brain endothelial cells. NEUROREPORT, 11(5), 1081-1084. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/00001756-200004070-00035 | |
| Abstract: | We report that extracellular matrix and neurons modulate the expression of occludin, one of the main components of tight junctions, by rat brain endothelial cells (RBE4.B). Of the three extracellular matrix proteins which we tested (collagen I, collagen IV, and laminin), collagen IV stimulated at the best the expression of occludin mRNA. The corresponding protein, however, was not synthesized. Significant amounts of occludin accumulated only when RBE4.B cells were cultured on collagen IV-coated inserts, in the presence of cortical neurons, plated on laminin-coated companion wells. Finally, occludin segregated at the cell periphery, only when endothelial cells were co- cultured with neurons for ≥ 1 week. (C) 2000 Lippincott Williams and Wilkins. | |
| Settore Scientifico Disciplinare: | Settore BIO/10 - Biochimica Settore CHIM/09 - Farmaceutico Tecnologico Applicativo Settore MED/26 - Neurologia | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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