Recently, the LRP10 gene has been associated with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), and dementia with Lewy bodies (DLB). The aim of the present study was to evaluate the presence of mutations of the LRP10 gene in patients with PD or DLB from Southern Italy. Sequencing analysis revealed only 2 missense and 3 synonymous variants in patients and control subjects and a rare variant p.L622F in a PD case. These results suggest that LRP10 mutations are not a frequent cause of PD and DLB in Southern Italy.

Gagliardi Monica, P.R. (2020). Analysis of the LRP10 gene in patients with Parkinson's disease and dementia with Lewy bodies from Southern Italy. NEUROLOGICAL SCIENCES [10.1007/s10072-020-04747-1].

Analysis of the LRP10 gene in patients with Parkinson's disease and dementia with Lewy bodies from Southern Italy

D'Amelio Marco;
2020-01-01

Abstract

Recently, the LRP10 gene has been associated with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), and dementia with Lewy bodies (DLB). The aim of the present study was to evaluate the presence of mutations of the LRP10 gene in patients with PD or DLB from Southern Italy. Sequencing analysis revealed only 2 missense and 3 synonymous variants in patients and control subjects and a rare variant p.L622F in a PD case. These results suggest that LRP10 mutations are not a frequent cause of PD and DLB in Southern Italy.
Settore MED/26 - Neurologia
Gagliardi Monica, P.R. (2020). Analysis of the LRP10 gene in patients with Parkinson's disease and dementia with Lewy bodies from Southern Italy. NEUROLOGICAL SCIENCES [10.1007/s10072-020-04747-1].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/437098
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