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EnglishThe serum levels of lysosomal cathepsin B and L and Stefin A, an intracellular inhibitor of these proteolytic enzymes, were determined in patients with hepatocellular carcinoma (HCC) and/or liver cirrhosis (LC) and correlated with some clinical and biochemical parameters of these diseases. Cathepsin B serum levels were increased in HCC and in LC patients as compared to normal subjects (p < 0.001). However no difference was observed between HCC and LC groups. Interestingly, a significant relationship was evidenced between cathepsin B serum content and the grade of severity of cirrhosis (r = 0.41; p < 0.001). Cathepsin L was significantly elevated only in sera of cancer patients as compared to normal subjects or LC patients (p < 0.001) and significantly correlated with the number of malignant lesions (r = 0.49; p = 0.001). Stefin A serum levels were increased in HCC and LC patients as compared to healthy subjects (p < 0.02). However, these levels were significantly higher in the LC group as compared to the HCC group (p < 0.05). In cancer patients, a significant relationship was observed between Stefin A serum content and tumor size (r = 0.35; p < 0.05), number of neoplastic lesions (r = 0.556; p < 0.001) and serum a-fetoprotein (r = 0.38; p < 0.01). These data suggest that cathepsin B and L and Stefin A may be potentially useful as additional biochemical parameters to monitor the therapeutic response of these diseases to clinical treatments and to identify patients with cirrhosis developing precancerous lesions. © 1997 S. Karger AG, Basel.
Leto G., Tumminello F.-M., Pizzolanti G., Montalto G., Soresi M., & Gebbia N. (1997). Lysosomal Cathepsins B and L and Stef in A Blood Levels in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis: Potential Clinical Implications. ONCOLOGY, 54(1), 79-83.
| Data di pubblicazione: | 1997 | |
| Titolo: | Lysosomal Cathepsins B and L and Stef in A Blood Levels in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis: Potential Clinical Implications | |
| Autori: | ||
| Citazione: | Leto G., Tumminello F.-M., Pizzolanti G., Montalto G., Soresi M., & Gebbia N. (1997). Lysosomal Cathepsins B and L and Stef in A Blood Levels in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis: Potential Clinical Implications. ONCOLOGY, 54(1), 79-83. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1159/000227666 | |
| Abstract: | The serum levels of lysosomal cathepsin B and L and Stefin A, an intracellular inhibitor of these proteolytic enzymes, were determined in patients with hepatocellular carcinoma (HCC) and/or liver cirrhosis (LC) and correlated with some clinical and biochemical parameters of these diseases. Cathepsin B serum levels were increased in HCC and in LC patients as compared to normal subjects (p < 0.001). However no difference was observed between HCC and LC groups. Interestingly, a significant relationship was evidenced between cathepsin B serum content and the grade of severity of cirrhosis (r = 0.41; p < 0.001). Cathepsin L was significantly elevated only in sera of cancer patients as compared to normal subjects or LC patients (p < 0.001) and significantly correlated with the number of malignant lesions (r = 0.49; p = 0.001). Stefin A serum levels were increased in HCC and LC patients as compared to healthy subjects (p < 0.02). However, these levels were significantly higher in the LC group as compared to the HCC group (p < 0.05). In cancer patients, a significant relationship was observed between Stefin A serum content and tumor size (r = 0.35; p < 0.05), number of neoplastic lesions (r = 0.556; p < 0.001) and serum a-fetoprotein (r = 0.38; p < 0.01). These data suggest that cathepsin B and L and Stefin A may be potentially useful as additional biochemical parameters to monitor the therapeutic response of these diseases to clinical treatments and to identify patients with cirrhosis developing precancerous lesions. © 1997 S. Karger AG, Basel. | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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