Some haematic parameters were investigated in female COBS mice treated with 7 alpha, 17 beta Dimethyltestcsterone (DMT). The drug causes an increase of circulating platelets in normal mice. Bone marrow graft from DMT-treated donors facilitates in irradiated mice repopulation of white blood cells and platelets but lowers % survival. These data are interpreted on the basis of a commitment and a loss of self-maintenance induced by DMT on CFUs compartment. © 1979 The Italian Pharmacological Society.
D.'Alessandre N., Gebbia N., Biondo F., Campio L., Leto G., Tumminello F., et al. (1979). Haemopoietic effects of 7 alpha, 17 beta Dimethyltestosterone. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 11(2), 81-94 [10.1016/S0031-6989(79)80062-4].
Haemopoietic effects of 7 alpha, 17 beta Dimethyltestosterone
Gebbia N.;Leto G.Investigation
;Rausa L.
1979
Abstract
Some haematic parameters were investigated in female COBS mice treated with 7 alpha, 17 beta Dimethyltestcsterone (DMT). The drug causes an increase of circulating platelets in normal mice. Bone marrow graft from DMT-treated donors facilitates in irradiated mice repopulation of white blood cells and platelets but lowers % survival. These data are interpreted on the basis of a commitment and a loss of self-maintenance induced by DMT on CFUs compartment. © 1979 The Italian Pharmacological Society.
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