Some haematic parameters were investigated in female COBS mice treated with 7 alpha, 17 beta Dimethyltestcsterone (DMT). The drug causes an increase of circulating platelets in normal mice. Bone marrow graft from DMT-treated donors facilitates in irradiated mice repopulation of white blood cells and platelets but lowers % survival. These data are interpreted on the basis of a commitment and a loss of self-maintenance induced by DMT on CFUs compartment. © 1979 The Italian Pharmacological Society.
D.'Alessandre N., Gebbia N., Biondo F., Campio L., Leto G., Tumminello F., et al. (1979). Haemopoietic effects of 7 alpha, 17 beta Dimethyltestosterone. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 11(2), 81-94.
Data di pubblicazione: | 1979 |
Titolo: | Haemopoietic effects of 7 alpha, 17 beta Dimethyltestosterone |
Autori: | |
Citazione: | D.'Alessandre N., Gebbia N., Biondo F., Campio L., Leto G., Tumminello F., et al. (1979). Haemopoietic effects of 7 alpha, 17 beta Dimethyltestosterone. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 11(2), 81-94. |
Rivista: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0031-6989(79)80062-4 |
Abstract: | Some haematic parameters were investigated in female COBS mice treated with 7 alpha, 17 beta Dimethyltestcsterone (DMT). The drug causes an increase of circulating platelets in normal mice. Bone marrow graft from DMT-treated donors facilitates in irradiated mice repopulation of white blood cells and platelets but lowers % survival. These data are interpreted on the basis of a commitment and a loss of self-maintenance induced by DMT on CFUs compartment. © 1979 The Italian Pharmacological Society. |
Appare nelle tipologie: | 1.01 Articolo in rivista |
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