There is emerging clinical evidence that amsacrine (m-AMSA) administration may be associated with cardiotoxic effects such as severe, even fatal, ventricular arrhythmias and impairment of the inotropic performance of the heart. Information on the cardiac effects of m-AMSA in animals is scanty. Studies on mice, dogs, and monkeys have not evidenced the cardiotoxicity of the compound. The data presented in this paper show that m-AMSA causes acute ECG alterations in normal rabbits and a dose-related negative inotropic effect on the isolated rabbit heart, suggesting that this species may be a useful model for the study of the cardiac actions of this antiblastic.

D'Alessandro N., Gebbia N., Crescimanno M., Flandina C., Leto G., Tumminello F.M., et al. (1983). Effects of amsacrine (m-AMSA) a new aminoacridine antitumor drug, on the rabbit heart. CANCER TREATMENT REPORTS, 67(5), 467-474.

Effects of amsacrine (m-AMSA) a new aminoacridine antitumor drug, on the rabbit heart

D'Alessandro N.;Gebbia N.;Flandina C.;Leto G.
Investigation
;
Tumminello F. M.;
1983-01-01

Abstract

There is emerging clinical evidence that amsacrine (m-AMSA) administration may be associated with cardiotoxic effects such as severe, even fatal, ventricular arrhythmias and impairment of the inotropic performance of the heart. Information on the cardiac effects of m-AMSA in animals is scanty. Studies on mice, dogs, and monkeys have not evidenced the cardiotoxicity of the compound. The data presented in this paper show that m-AMSA causes acute ECG alterations in normal rabbits and a dose-related negative inotropic effect on the isolated rabbit heart, suggesting that this species may be a useful model for the study of the cardiac actions of this antiblastic.
D'Alessandro N., Gebbia N., Crescimanno M., Flandina C., Leto G., Tumminello F.M., et al. (1983). Effects of amsacrine (m-AMSA) a new aminoacridine antitumor drug, on the rabbit heart. CANCER TREATMENT REPORTS, 67(5), 467-474.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/434910
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