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EnglishExperimental and clinical studies have recently shown a significant correlation between increased activity levels of lysosomal proteinases Cathepsin B, L in tumor tissues and malignant progression. On the basis of these findings we have undertaken some preliminary studies to evaluate the clinical impact of these enzymes and their intracellular inhibitor Stefin A in patients with malignant and non malignant liver diseases. The serum levels of Cathepsin B, L and Stefin A resulted significantly increased (mean 7 folds) in patients with liver diseases as compared to healthy subjects . these findings suggest that Cathepsin B, Cathepsin L, and Stefin A serum levels may be potentially useful as prognostic parameters for the clinical and therapeutic management of patients with hepatocellular carcinoma and/or liver cirrhosis
Tumminello F.M., Pizzolanti G., Gebbia N., & Leto G. (1995). Stefin A and cathepsin B and L circulating serum levels in patients with malignant or non-malignant liver diseases: A preliminary report. MEDICAL SCIENCE RESEARCH, 23(11), 741-742.
| Data di pubblicazione: | 1995 | |
| Titolo: | Stefin A and cathepsin B and L circulating serum levels in patients with malignant or non-malignant liver diseases: A preliminary report | |
| Autori: | LETO, Gaetano (Corresponding) | |
| Citazione: | Tumminello F.M., Pizzolanti G., Gebbia N., & Leto G. (1995). Stefin A and cathepsin B and L circulating serum levels in patients with malignant or non-malignant liver diseases: A preliminary report. MEDICAL SCIENCE RESEARCH, 23(11), 741-742. | |
| Rivista: | ||
| Abstract: | Experimental and clinical studies have recently shown a significant correlation between increased activity levels of lysosomal proteinases Cathepsin B, L in tumor tissues and malignant progression. On the basis of these findings we have undertaken some preliminary studies to evaluate the clinical impact of these enzymes and their intracellular inhibitor Stefin A in patients with malignant and non malignant liver diseases. The serum levels of Cathepsin B, L and Stefin A resulted significantly increased (mean 7 folds) in patients with liver diseases as compared to healthy subjects . these findings suggest that Cathepsin B, Cathepsin L, and Stefin A serum levels may be potentially useful as prognostic parameters for the clinical and therapeutic management of patients with hepatocellular carcinoma and/or liver cirrhosis | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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