Statin therapy is generally well tolerated and very effective in the prevention and treatment of cardiovascular disease, regardless of cholesterol levels; however, it can be associated with various adverse events (myalgia, myopathy, rhabdomyolysis, and diabetes mellitus, among others). Patients frequently discontinue statin therapy without medical advice because of perceived side effects and consequently increase their risk for cardiovascular events. In patients with statin intolerance, it may be advisable to change the dose, switch to a different statin, or try an alternate-day regimen. If intolerance is associated with all statins—even at the lowest dose—non-statin drugs and certain nutraceuticals can be considered. This review focuses on the definition of statin intolerance and on the development of clinical and therapeutic strategies for its management, including emerging alternative therapies.

Toth P.P., Patti A.M., Giglio R.V., Nikolic D., Castellino G., Rizzo Manfredi, et al. (2018). Management of Statin Intolerance in 2018: Still More Questions Than Answers. AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 18(3), 157-173 [10.1007/s40256-017-0259-7].

Management of Statin Intolerance in 2018: Still More Questions Than Answers

Patti A. M.;Giglio R. V.;Nikolic D.;Castellino G.;Rizzo Manfredi;
2018

Abstract

Statin therapy is generally well tolerated and very effective in the prevention and treatment of cardiovascular disease, regardless of cholesterol levels; however, it can be associated with various adverse events (myalgia, myopathy, rhabdomyolysis, and diabetes mellitus, among others). Patients frequently discontinue statin therapy without medical advice because of perceived side effects and consequently increase their risk for cardiovascular events. In patients with statin intolerance, it may be advisable to change the dose, switch to a different statin, or try an alternate-day regimen. If intolerance is associated with all statins—even at the lowest dose—non-statin drugs and certain nutraceuticals can be considered. This review focuses on the definition of statin intolerance and on the development of clinical and therapeutic strategies for its management, including emerging alternative therapies.
Toth P.P., Patti A.M., Giglio R.V., Nikolic D., Castellino G., Rizzo Manfredi, et al. (2018). Management of Statin Intolerance in 2018: Still More Questions Than Answers. AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 18(3), 157-173 [10.1007/s40256-017-0259-7].
File in questo prodotto:
File Dimensione Formato  
Management of Statin Intolerance in 2018 Still More Questions Than Answers.pdf

accesso aperto

Tipologia: Post-print
Dimensione 576.62 kB
Formato Adobe PDF
576.62 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/433778
Citazioni
  • ???jsp.display-item.citation.pmc??? 35
  • Scopus 85
  • ???jsp.display-item.citation.isi??? 79
social impact