Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts.

Saladino, M.L., Markowska, M., Carmone, C., Cancemi, P., Alduina, R., Presentato, A., et al. (2020). Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials. MATERIALS, 13(8), 1980 [10.3390/ma13081980].

Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials

Saladino, Maria Luisa
;
Carmone, Clara;Cancemi, Patrizia;Alduina, Rosa;Presentato, Alessandro;Scaffaro, Roberto;
2020

Abstract

Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts.
Settore ING-IND/22 - Scienza E Tecnologia Dei Materiali
Settore CHIM/02 - Chimica Fisica
Saladino, M.L., Markowska, M., Carmone, C., Cancemi, P., Alduina, R., Presentato, A., et al. (2020). Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials. MATERIALS, 13(8), 1980 [10.3390/ma13081980].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/423277
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