Although the inherited quantitative and qualitative disorders of fibrinogen are rare, in the course of time patients may develop complications including episodes of arterial and venous thrombosis. It can be useful to complete the laboratory assessment of these clinical conditions with the evaluation of the haemorheological profile. The data obtained from this study showed that congenital afibrinogenemia was characterized by a primary plasma hypoviscosity, whereas congenital dysfibrinogenemia by a primary plasma hyperviscosity. Both these haemorheological alterations may concur, with different mechanisms, to the pathogenesis of thrombotic vascular complications.

Caimi G., Raso S., Napolitano M., Hopps E., Lo Presti R., Siragusa S. (2019). Haemorheological profile in congenital afibrinogenemia and in congenital dysfibrinogenemia: A clinical case report. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 73(4), 523-530 [10.3233/CH-180542].

Haemorheological profile in congenital afibrinogenemia and in congenital dysfibrinogenemia: A clinical case report

Caimi G.;Raso S.;Napolitano M.;Hopps E.;Lo Presti R.;Siragusa S.
2019-01-01

Abstract

Although the inherited quantitative and qualitative disorders of fibrinogen are rare, in the course of time patients may develop complications including episodes of arterial and venous thrombosis. It can be useful to complete the laboratory assessment of these clinical conditions with the evaluation of the haemorheological profile. The data obtained from this study showed that congenital afibrinogenemia was characterized by a primary plasma hypoviscosity, whereas congenital dysfibrinogenemia by a primary plasma hyperviscosity. Both these haemorheological alterations may concur, with different mechanisms, to the pathogenesis of thrombotic vascular complications.
Caimi G., Raso S., Napolitano M., Hopps E., Lo Presti R., Siragusa S. (2019). Haemorheological profile in congenital afibrinogenemia and in congenital dysfibrinogenemia: A clinical case report. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 73(4), 523-530 [10.3233/CH-180542].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/417834
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