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EnglishBackground: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. Methods: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI). Results: In this study, we have outlined the possible role of VRS in different pathological conditions. Conclusion: The new insights into the physiology of the CSF circulation may have important clinical relevance for understanding the mechanisms underlying brain pathologies and their cure. ©2016 Surgical Neurology International | Published by Wolters Kluwer - Medknow .
Cherian, I., Beltran, M., Kasper, E., Bhattarai, B., Munokami, S., & Grasso, G. (2016). Exploring the Virchow-Robin spaces function: A unified theory of brain diseases. SURGICAL NEUROLOGY INTERNATIONAL, 7(27), S711-S714.
| Data di pubblicazione: | 2016 |
| Titolo: | Exploring the Virchow-Robin spaces function: A unified theory of brain diseases |
| Autori: | GRASSO, Giovanni (Corresponding) |
| Citazione: | Cherian, I., Beltran, M., Kasper, E., Bhattarai, B., Munokami, S., & Grasso, G. (2016). Exploring the Virchow-Robin spaces function: A unified theory of brain diseases. SURGICAL NEUROLOGY INTERNATIONAL, 7(27), S711-S714. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.4103/2152-7806.192486 |
| Abstract: | Background: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. Methods: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI). Results: In this study, we have outlined the possible role of VRS in different pathological conditions. Conclusion: The new insights into the physiology of the CSF circulation may have important clinical relevance for understanding the mechanisms underlying brain pathologies and their cure. ©2016 Surgical Neurology International | Published by Wolters Kluwer - Medknow . |
| URL: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009288495&doi=10.4103/2152-7806.192486&partnerID=40&md5=ca1ebd56a0dafb65a9c6bcd1c3697695 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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| SNI-7-711.pdf | Versione Editoriale | Open Access Visualizza/Apri |
http://hdl.handle.net/10447/414262
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