We read with interest the D-CARE trial report by Robert Coleman and colleagues1 on the adjuvant administration of denosumab in patients with early-stage breast cancer. Despite the negative results, which pose concerns about high dose denosumab schedules in an adjuvant setting, this large and well- designed trial can provide useful clinical data that are usually difficult to obtain from observational studies, particularly regarding medication- related osteonecrosis of the jaw (MRONJ).
Fusco V., Campisi G., Bedogni A. (2020). Adjuvant denosumab in early breast-cancer. THE LANCET ONCOLOGY, 21(3), e124 [10.1016/S1470-2045(20)30066-8].
Adjuvant denosumab in early breast-cancer
Fusco V.;Campisi G.;Bedogni A.
2020-01-01
Abstract
We read with interest the D-CARE trial report by Robert Coleman and colleagues1 on the adjuvant administration of denosumab in patients with early-stage breast cancer. Despite the negative results, which pose concerns about high dose denosumab schedules in an adjuvant setting, this large and well- designed trial can provide useful clinical data that are usually difficult to obtain from observational studies, particularly regarding medication- related osteonecrosis of the jaw (MRONJ).
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