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EnglishWe read with interest the D-CARE trial report by Robert Coleman and colleagues1 on the adjuvant administration of denosumab in patients with early-stage breast cancer. Despite the negative results, which pose concerns about high dose denosumab schedules in an adjuvant setting, this large and well- designed trial can provide useful clinical data that are usually difficult to obtain from observational studies, particularly regarding medication- related osteonecrosis of the jaw (MRONJ).
Fusco V., Campisi G., & Bedogni A. (2020). Adjuvant denosumab in early breast-cancer. THE LANCET ONCOLOGY, 21(3), e124.
| Data di pubblicazione: | 2020 |
| Titolo: | Adjuvant denosumab in early breast-cancer |
| Autori: | |
| Citazione: | Fusco V., Campisi G., & Bedogni A. (2020). Adjuvant denosumab in early breast-cancer. THE LANCET ONCOLOGY, 21(3), e124. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S1470-2045(20)30066-8 |
| Abstract: | We read with interest the D-CARE trial report by Robert Coleman and colleagues1 on the adjuvant administration of denosumab in patients with early-stage breast cancer. Despite the negative results, which pose concerns about high dose denosumab schedules in an adjuvant setting, this large and well- designed trial can provide useful clinical data that are usually difficult to obtain from observational studies, particularly regarding medication- related osteonecrosis of the jaw (MRONJ). |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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