Within Sicilian flora, the genus Hypericum (Guttiferae) includes 10 native species, the most popular of which is H. perforatum. Hypericum’s most investigated active compounds belong to naphtodianthrones (hypericin, pseudohypericin) and phloroglucinols (hyperforin, adhyperforin), and the commercial value of the drug is graded according to its total hypericin content. Ethnobotanical sources attribute the therapeutic properties recognized for H. perforatum, also to other Hypericum species. However, their smaller distribution inside the territory suggests that an industrial use of such species, when collected from the wild, would result in an unacceptable depletion of their natural stands. This study investigated about the potential pharmacological properties of 48 accessions from six native species of Hypericum, including H. perforatum and five ‘minor’ species, also comparing, when possible, wild and cultivated sources. The variability in the content of active metabolites was remarkably high, and the differences within the species were often comparable to the differences among species. No difference was enlightened between wild and cultivated plants. A carefully planned cultivation of Hypericum seems the best option to achieve high and steady biomass yields, but there is a need for phytochemical studies, aimed to identify for multiplication the genotypes with the highest content of the active metabolites.

Lazzara S., Carrubba A., Napoli E. (2020). Variability of Hypericins and Hyperforin in Hypericum Species from the Sicilian Flora. CHEMISTRY & BIODIVERSITY, 17(1) [10.1002/cbdv.201900596].

Variability of Hypericins and Hyperforin in Hypericum Species from the Sicilian Flora

Lazzara S.
Membro del Collaboration Group
;
Carrubba A.
Membro del Collaboration Group
;
2020-01-01

Abstract

Within Sicilian flora, the genus Hypericum (Guttiferae) includes 10 native species, the most popular of which is H. perforatum. Hypericum’s most investigated active compounds belong to naphtodianthrones (hypericin, pseudohypericin) and phloroglucinols (hyperforin, adhyperforin), and the commercial value of the drug is graded according to its total hypericin content. Ethnobotanical sources attribute the therapeutic properties recognized for H. perforatum, also to other Hypericum species. However, their smaller distribution inside the territory suggests that an industrial use of such species, when collected from the wild, would result in an unacceptable depletion of their natural stands. This study investigated about the potential pharmacological properties of 48 accessions from six native species of Hypericum, including H. perforatum and five ‘minor’ species, also comparing, when possible, wild and cultivated sources. The variability in the content of active metabolites was remarkably high, and the differences within the species were often comparable to the differences among species. No difference was enlightened between wild and cultivated plants. A carefully planned cultivation of Hypericum seems the best option to achieve high and steady biomass yields, but there is a need for phytochemical studies, aimed to identify for multiplication the genotypes with the highest content of the active metabolites.
Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Lazzara S., Carrubba A., Napoli E. (2020). Variability of Hypericins and Hyperforin in Hypericum Species from the Sicilian Flora. CHEMISTRY & BIODIVERSITY, 17(1) [10.1002/cbdv.201900596].
File in questo prodotto:
File Dimensione Formato  
cbdv.201900596.pdf

Solo gestori archvio

Tipologia: Versione Editoriale
Dimensione 992.31 kB
Formato Adobe PDF
992.31 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Chembiodiv 2020.pdf

Open Access dal 30/11/2020

Tipologia: Post-print
Dimensione 624.22 kB
Formato Adobe PDF
624.22 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/405195
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 12
social impact