Uveal Melanoma (UM) represents the most common primary intraocular malignant tumor in adults. Although it originates from melanocytes as cutaneous melanoma, it shows significant clinical and biological differences with the latter, including high resistance to immune therapy. Indeed, UM can evade immune surveillance via multiple mechanisms, such as the expression of inhibitory checkpoints (e.g., PD-L1, CD47, CD200) and the production of IDO-1 and soluble FasL, among others. More in-depth understanding of these mechanisms will suggest potential targets for the design of novel and more effective management strategies for UM patients.

Basile M.S., Mazzon E., Fagone P., Longo A., Russo A., Fallico M., et al. (2019). Immunobiology of Uveal Melanoma: State of the Art and Therapeutic Targets. FRONTIERS IN ONCOLOGY, 9, 1145 [10.3389/fonc.2019.01145].

Immunobiology of Uveal Melanoma: State of the Art and Therapeutic Targets

Mazzon E.;Russo A.;Bonfiglio V.;Avitabile T.;
2019-01-01

Abstract

Uveal Melanoma (UM) represents the most common primary intraocular malignant tumor in adults. Although it originates from melanocytes as cutaneous melanoma, it shows significant clinical and biological differences with the latter, including high resistance to immune therapy. Indeed, UM can evade immune surveillance via multiple mechanisms, such as the expression of inhibitory checkpoints (e.g., PD-L1, CD47, CD200) and the production of IDO-1 and soluble FasL, among others. More in-depth understanding of these mechanisms will suggest potential targets for the design of novel and more effective management strategies for UM patients.
http://www.frontiersin.org/Oncology/about
Basile M.S., Mazzon E., Fagone P., Longo A., Russo A., Fallico M., et al. (2019). Immunobiology of Uveal Melanoma: State of the Art and Therapeutic Targets. FRONTIERS IN ONCOLOGY, 9, 1145 [10.3389/fonc.2019.01145].
File in questo prodotto:
File Dimensione Formato  
basile front oncol 2019 1.pdf

accesso aperto

Tipologia: Post-print
Dimensione 917.46 kB
Formato Adobe PDF
917.46 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/402174
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 28
social impact