The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation

Martocchia, A; Gallucci, M; Noale, M; Maggi, S; Cassol, M; Stefanelli, M; Postacchini, D; Proietti, A; Barbagallo, M; DOMINGUEZ RODRIGUEZ, LJ; Ferri, C; Desideri, G; Toussan, L; Pastore, F; Falaschi, GM; Paolisso, G; Falaschi, P; Falaschi, P; Martocchia, A; Stefanelli, M; Toussan, L; Pastore, F; Eleuteri, S; Falaschi, GM; Proietti, A; D'Urso, R; Petricca, L; Cardelli, P; Gallucci, M; Oddo, MG; Maggi, S; Noale, M; Postacchini, D; Giuli, C; Macchiati, I; Migale, M; Sorvillo, F; Brunelli, R; Francavilla, M; Santini, S; Marini, L; Santillo, E; Fallavollita, L; Cassol, M; Rotunno, S; Paolisso, G; Barbieri, M; Angellotti, E; Ferri, C; Ludovici, V; Cheli, P; Del Pinto, R; Desideri, G; Barbagallo, M; Dominguez, LJ; Di Bella, G; Culotta, V

doi:10.1007/s40520-019-01322-3

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Background: Elderly people are exposed to an increased load of stressful events and neuro-hormonal stimulation is a key finding in metabolic syndrome and its related disorders. Aims: To determine the role of cortisol in elderly subjects, with or without metabolic syndrome (MetS), by means of a national multicentre observational study, AGICO (AGIng and Cortisol). Methods: From 2012 to 2017, the AGICO study enrolled n.339 subjects (aged > 65), after obtaining their informed consent. The investigators assessed a cardio-metabolic panel (including electrocardiogram, carotid ultrasonography and echocardiography), the presence of MetS (on Adult Treatment Panel III criteria), a neurological examination (including brain imaging), and cortisol activity (using a consecutive collection of diurnal and nocturnal urine). Results: In the patients presenting with MetS, the standardized diurnal and nocturnal cortisol excretion rates were 210.7 ± 145.5 and 173.7 ± 118.1 (mean ± standard deviation) μg/g creatinine/12 h; in those without MetS, the standardized diurnal and nocturnal cortisol excretion rates were 188.7 ± 92.7 and 144.1 ± 82.3 μg/g creatinine/12 h, respectively (nocturnal urinary cortisol in patients with MetS versus those without MetS p = 0.05, female patients with MetS vs female patients without MetS, p < 0.025). A significant positive correlation was found between the CRP levels and both the diurnal and nocturnal urinary cortisol levels with r = 0.187 (p < 0.025) and r = 0.411 (p < 0.00000001), respectively. Discussion: The elderly patients with MetS showed a trend towards increased standardized nocturnal cortisol excretions, with particular regard to the female subjects. Conclusion: The positive correlation between cortisol excretion and low-grade inflammation suggests a common mechanism driving both hormonal and inflammatory changes.

Data di pubblicazione:	2019
Titolo:	The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation
Autori:	Martocchia A. GALLUCCI, Giulia Carmen Noale M. Maggi S. Cassol M. Stefanelli M. Postacchini D. PROIETTI, Paolo BARBAGALLO, Mario DOMINGUEZ RODRIGUEZ, Ligia Juliana FERRIGNO, Carlo Desideri G. Toussan L. PASTORELLA, Fabio Falaschi G. M. Paolisso G. Falaschi P. Falaschi P. Martocchia A. Stefanelli M. Toussan L. PASTORELLA, Fabio Eleuteri S. Falaschi G. M. PROIETTI, Paolo D'URSO, Carmela Petricca L. Cardelli P. GALLUCCI, Giulia Carmen Oddo M. G. Maggi S. Noale M. Postacchini D. Giuli C. Macchiati I. Migale M. Sorvillo F. BRUNELLI, Ulderico Francavilla M. Santini S. Marini L. Santillo E. Fallavollita L. Cassol M. Rotunno S. Paolisso G. BARBIERI, Maurizio Angellotti E. FERRIGNO, Carlo Ludovici V. Cheli P. Del Pinto R. Desideri G. Barbagallo M. Dominguez L. J. Di Bella G. Culotta V. mostra contributor esterni nascondi contributor esterni
Citazione:	Martocchia A., Gallucci M., Noale M., Maggi S., Cassol M., Stefanelli M., et al. (2019). The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation. AGING CLINICAL AND EXPERIMENTAL RESEARCH.
Rivista:	AGING CLINICAL AND EXPERIMENTAL RESEARCH
Digital Object Identifier (DOI):	http://dx.doi.org/10.1007/s40520-019-01322-3
Abstract:	Background: Elderly people are exposed to an increased load of stressful events and neuro-hormonal stimulation is a key finding in metabolic syndrome and its related disorders. Aims: To determine the role of cortisol in elderly subjects, with or without metabolic syndrome (MetS), by means of a national multicentre observational study, AGICO (AGIng and Cortisol). Methods: From 2012 to 2017, the AGICO study enrolled n.339 subjects (aged > 65), after obtaining their informed consent. The investigators assessed a cardio-metabolic panel (including electrocardiogram, carotid ultrasonography and echocardiography), the presence of MetS (on Adult Treatment Panel III criteria), a neurological examination (including brain imaging), and cortisol activity (using a consecutive collection of diurnal and nocturnal urine). Results: In the patients presenting with MetS, the standardized diurnal and nocturnal cortisol excretion rates were 210.7 ± 145.5 and 173.7 ± 118.1 (mean ± standard deviation) μg/g creatinine/12 h; in those without MetS, the standardized diurnal and nocturnal cortisol excretion rates were 188.7 ± 92.7 and 144.1 ± 82.3 μg/g creatinine/12 h, respectively (nocturnal urinary cortisol in patients with MetS versus those without MetS p = 0.05, female patients with MetS vs female patients without MetS, p < 0.025). A significant positive correlation was found between the CRP levels and both the diurnal and nocturnal urinary cortisol levels with r = 0.187 (p < 0.025) and r = 0.411 (p < 0.00000001), respectively. Discussion: The elderly patients with MetS showed a trend towards increased standardized nocturnal cortisol excretions, with particular regard to the female subjects. Conclusion: The positive correlation between cortisol excretion and low-grade inflammation suggests a common mechanism driving both hormonal and inflammatory changes.
URL:	http://link.springer.com/journal/volumesAndIssues/40520
Settore Scientifico Disciplinare:	Settore MED/09 - Medicina Interna
Appare nelle tipologie:	1.01 Articolo in rivista

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