Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset able to recognize glycolipid antigens. Their function remains unclear, but studies have pointed out their ability to modulate the immune system through the promotion of specific cytokine milieu. In this review, we discussed the possible role of iNKT in pSS development, as well as their implications as future markers of disease activity.

Rizzo C., Barbera L.L., Pizzo M.L., Ciccia F., Sireci G., Guggino G. (2019). Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(21), 5435 [10.3390/ijms20215435].

Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome

Ciccia F.;Sireci G.;Guggino G.
2019-01-01

Abstract

Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset able to recognize glycolipid antigens. Their function remains unclear, but studies have pointed out their ability to modulate the immune system through the promotion of specific cytokine milieu. In this review, we discussed the possible role of iNKT in pSS development, as well as their implications as future markers of disease activity.
Settore MED/16 - Reumatologia
https://www.mdpi.com/1422-0067/20/21/5435/pdf
Rizzo C., Barbera L.L., Pizzo M.L., Ciccia F., Sireci G., Guggino G. (2019). Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(21), 5435 [10.3390/ijms20215435].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/401692
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