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EnglishPeritoneal involvement in cancer is the harbinger of a particularly unfavorable prognosis. The peritoneal cavity microenvironment is skewed toward immunoregulatory conditions promoted by macrophage populations and innate-like B-1 B cells, which provide immune privilege to malignant cell foci. In this issue of Cancer Research, Haro and colleagues demonstrate that triggering innate IgM-mediated B-1a immune responses via pathogen- or danger-associated molecular pattern recognition exerts antitumor effects on peritoneal metastases by inducing classical complement cascade activation. Exploitation of innate B-1 humoral responses and noncellular immunity is a promising strategy to counter the "castling" of metastatic tumor cells in the peritoneal immunoprivileged site.
Tripodo C. (2019). Time for a "plan B" in peritoneal metastatic disease. CANCER RESEARCH, 79(1), 5-6.
| Data di pubblicazione: | 2019 |
| Titolo: | Time for a "plan B" in peritoneal metastatic disease |
| Autori: | |
| Citazione: | Tripodo C. (2019). Time for a "plan B" in peritoneal metastatic disease. CANCER RESEARCH, 79(1), 5-6. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1158/0008-5472.CAN-18-3553 |
| Abstract: | Peritoneal involvement in cancer is the harbinger of a particularly unfavorable prognosis. The peritoneal cavity microenvironment is skewed toward immunoregulatory conditions promoted by macrophage populations and innate-like B-1 B cells, which provide immune privilege to malignant cell foci. In this issue of Cancer Research, Haro and colleagues demonstrate that triggering innate IgM-mediated B-1a immune responses via pathogen- or danger-associated molecular pattern recognition exerts antitumor effects on peritoneal metastases by inducing classical complement cascade activation. Exploitation of innate B-1 humoral responses and noncellular immunity is a promising strategy to counter the "castling" of metastatic tumor cells in the peritoneal immunoprivileged site. |
| URL: | http://cancerres.aacrjournals.org/content/79/1/5.full-text.pdf |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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