Peritoneal involvement in cancer is the harbinger of a particularly unfavorable prognosis. The peritoneal cavity microenvironment is skewed toward immunoregulatory conditions promoted by macrophage populations and innate-like B-1 B cells, which provide immune privilege to malignant cell foci. In this issue of Cancer Research, Haro and colleagues demonstrate that triggering innate IgM-mediated B-1a immune responses via pathogen- or danger-associated molecular pattern recognition exerts antitumor effects on peritoneal metastases by inducing classical complement cascade activation. Exploitation of innate B-1 humoral responses and noncellular immunity is a promising strategy to counter the "castling" of metastatic tumor cells in the peritoneal immunoprivileged site.

Tripodo C. (2019). Time for a "plan B" in peritoneal metastatic disease. CANCER RESEARCH, 79(1), 5-6 [10.1158/0008-5472.CAN-18-3553].

Time for a "plan B" in peritoneal metastatic disease

Tripodo C.
2019-01-01

Abstract

Peritoneal involvement in cancer is the harbinger of a particularly unfavorable prognosis. The peritoneal cavity microenvironment is skewed toward immunoregulatory conditions promoted by macrophage populations and innate-like B-1 B cells, which provide immune privilege to malignant cell foci. In this issue of Cancer Research, Haro and colleagues demonstrate that triggering innate IgM-mediated B-1a immune responses via pathogen- or danger-associated molecular pattern recognition exerts antitumor effects on peritoneal metastases by inducing classical complement cascade activation. Exploitation of innate B-1 humoral responses and noncellular immunity is a promising strategy to counter the "castling" of metastatic tumor cells in the peritoneal immunoprivileged site.
http://cancerres.aacrjournals.org/content/79/1/5.full-text.pdf
Tripodo C. (2019). Time for a "plan B" in peritoneal metastatic disease. CANCER RESEARCH, 79(1), 5-6 [10.1158/0008-5472.CAN-18-3553].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/401660
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