Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause, almost exclusively occurring in people aged over 50 and often associated with giant cell arteritis. The evidence that PMR occurs almost exclusively in individuals aged over 50 may indicate that age-related immune alterations in genetically predisposed subjects contribute to development of the disease. Several infectious agents have been investigated as possible triggers of PMR even though the results are inconclusive. Activation of the innate and adaptive immune systems has been proved in PMR patients as demonstrated by the activation of dendritic cells and monocytes/macrophages and the altered balance between Th17 and Treg cells. Disturbed B cell distribution and function have been also demonstrated in PMR patients suggesting a pathogenesis more complex than previously imagined. In this review we will discuss the recent findings regarding the pathogenesis of PMR.

Guggino G., Ferrante A., Macaluso F., Triolo G., Ciccia F. (2018). Pathogenesis of polymyalgia rheumatica. REUMATISMO, 70(1), 10-17 [10.4081/reumatismo.2018.1048].

Pathogenesis of polymyalgia rheumatica

Guggino G.;Ferrante A.
Membro del Collaboration Group
;
Triolo G.
Membro del Collaboration Group
;
Ciccia F.
2018-01-01

Abstract

Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause, almost exclusively occurring in people aged over 50 and often associated with giant cell arteritis. The evidence that PMR occurs almost exclusively in individuals aged over 50 may indicate that age-related immune alterations in genetically predisposed subjects contribute to development of the disease. Several infectious agents have been investigated as possible triggers of PMR even though the results are inconclusive. Activation of the innate and adaptive immune systems has been proved in PMR patients as demonstrated by the activation of dendritic cells and monocytes/macrophages and the altered balance between Th17 and Treg cells. Disturbed B cell distribution and function have been also demonstrated in PMR patients suggesting a pathogenesis more complex than previously imagined. In this review we will discuss the recent findings regarding the pathogenesis of PMR.
Settore MED/16 - Reumatologia
http://www.reumatismo.org/index.php/reuma/article/download/1048/778
Guggino G., Ferrante A., Macaluso F., Triolo G., Ciccia F. (2018). Pathogenesis of polymyalgia rheumatica. REUMATISMO, 70(1), 10-17 [10.4081/reumatismo.2018.1048].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/399886
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