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EnglishObjective. To evaluate whether CD3 staining performed routinely on temporal artery biopsy specimens might improve the sensitivity of temporal artery biopsy in patients with biopsy-negative GCA. Methods. Two hundred and seventy biopsies were considered for this study, stained with haematoxylin and eosin and with an anti-CD3 antibody. Results. The addition of CD3 staining modified the sensibility and the specificity of the histologic examination in 89.47 and 95.00%, respectively, with a positive and negative predictive values of 97.00 and 79.78%. Conclusion. The addition of CD3 immunostaining to the classic histologic evaluation is accompanied by a significant increase in the sensibility with a comparable specificity. The Author(s) 2018.
| Data di pubblicazione: | 2018 |
| Titolo: | CD3 immunohistochemistry is helpful in the diagnosis of giant cell arteritis |
| Autori: | |
| Citazione: | Ciccia F., Ferrante A., Guggino G., Cavazza A., Salvarani C., & Rizzo A. (2018). CD3 immunohistochemistry is helpful in the diagnosis of giant cell arteritis. RHEUMATOLOGY, 57(8), 1377-1380. |
| Rivista: | |
| Digital Object Identifier (DOI): | 10.1093/rheumatology/key106 |
| Abstract: | Objective. To evaluate whether CD3 staining performed routinely on temporal artery biopsy specimens might improve the sensitivity of temporal artery biopsy in patients with biopsy-negative GCA. Methods. Two hundred and seventy biopsies were considered for this study, stained with haematoxylin and eosin and with an anti-CD3 antibody. Results. The addition of CD3 staining modified the sensibility and the specificity of the histologic examination in 89.47 and 95.00%, respectively, with a positive and negative predictive values of 97.00 and 79.78%. Conclusion. The addition of CD3 immunostaining to the classic histologic evaluation is accompanied by a significant increase in the sensibility with a comparable specificity. The Author(s) 2018. |
| URL: | http://rheumatology.oxfordjournals.org/ |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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