Background and aims: The present study aims to assess possible qEEG differences between newly diagnosed multiple sclerosis (MS) patients with or without cognitive impairment (CI). Methods: We enrolled 22 patients (18-55-years-old) treated with first-line drugs for <6 months, and 11 healthy controls. All subjects underwent neuropsychological assessment including BICAMS and BDI. EEG recordings were performed during a cognitive task (computerised “SDMT” subtest of BICAMS) and at rest. Based on neuropsychological assessment, patients were considered as affected (MSCI group) or not (MS group) by cognitive impairment. We analysed data comparing MSCI patients matched by sex, age (±5years) and education to an MS patient and a control. Power spectrum analysis (theta, alpha and beta bands and sub-bands) was performed (EEGLAB extension for Matlab). Data were log-transformed and analysed through repente measures ANOVA. Results: A significant interaction group (MSCI, MS, Controls) x condition (rest, task) x band (alpha, beta, theta) was observed. Post-hoc analyses showed significant differences between MSCI and both MS and Controls in all the bands at rest (p<.05). In task condition MSCI significantly differed from controls in alpha and theta bands (p<.05) but not beta (p=.9). Moreover, while a significant power spectrum difference was found in all bands in both MS and Controls between rest and tak condition, MSCI didn’t show any difference in alpha power (p=.6). Conclusion: If confirmed in larger series, our results seem to support the hypothesis that qEEG differences exist among MSCI, MS and healthy controls, opening to a possible neurophysiological hallmark of cognitive impairment in MS patients.

Nucera, B., Giglia, G., Ragonese, P., Gangitano, M., Vullo, P., Realmuto, S., et al. (2019). Quantitative EEG differentiates multiple sclerosis with and without cognitive impairment from healthy controls at the beginning of the disease: preliminary data. EUROPEAN JOURNAL OF NEUROLOGY, 26(supplement 1), 243-243.

Quantitative EEG differentiates multiple sclerosis with and without cognitive impairment from healthy controls at the beginning of the disease: preliminary data

Nucera, B;Giglia, G;Ragonese, P;Gangitano, M;Vullo, P;Realmuto, S;Sardo, P;Salemi, G;Ferraro, G
2019-01-01

Abstract

Background and aims: The present study aims to assess possible qEEG differences between newly diagnosed multiple sclerosis (MS) patients with or without cognitive impairment (CI). Methods: We enrolled 22 patients (18-55-years-old) treated with first-line drugs for <6 months, and 11 healthy controls. All subjects underwent neuropsychological assessment including BICAMS and BDI. EEG recordings were performed during a cognitive task (computerised “SDMT” subtest of BICAMS) and at rest. Based on neuropsychological assessment, patients were considered as affected (MSCI group) or not (MS group) by cognitive impairment. We analysed data comparing MSCI patients matched by sex, age (±5years) and education to an MS patient and a control. Power spectrum analysis (theta, alpha and beta bands and sub-bands) was performed (EEGLAB extension for Matlab). Data were log-transformed and analysed through repente measures ANOVA. Results: A significant interaction group (MSCI, MS, Controls) x condition (rest, task) x band (alpha, beta, theta) was observed. Post-hoc analyses showed significant differences between MSCI and both MS and Controls in all the bands at rest (p<.05). In task condition MSCI significantly differed from controls in alpha and theta bands (p<.05) but not beta (p=.9). Moreover, while a significant power spectrum difference was found in all bands in both MS and Controls between rest and tak condition, MSCI didn’t show any difference in alpha power (p=.6). Conclusion: If confirmed in larger series, our results seem to support the hypothesis that qEEG differences exist among MSCI, MS and healthy controls, opening to a possible neurophysiological hallmark of cognitive impairment in MS patients.
5th Congress of the European-Academy-of-Neurology (EAN)
Oslo, NORWAY
JUN 29-JUL 02, 2019
5th
Nucera, B., Giglia, G., Ragonese, P., Gangitano, M., Vullo, P., Realmuto, S., et al. (2019). Quantitative EEG differentiates multiple sclerosis with and without cognitive impairment from healthy controls at the beginning of the disease: preliminary data. EUROPEAN JOURNAL OF NEUROLOGY, 26(supplement 1), 243-243.
File in questo prodotto:
File Dimensione Formato  
2019-European_Journal_of_Neurology (2) 132.pdf

Solo gestori archvio

Descrizione: estratto di abstract book pubblicato su rivista
Tipologia: Altro materiale (es. dati della ricerca)
Dimensione 351.69 kB
Formato Adobe PDF
351.69 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/394599
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact