Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.
Domarco O., Lotsch D., Schreiber J., Dinhof C., Van Schoonhoven S., Garcia M.D., et al. (2017). Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells. DALTON TRANSACTIONS, 46(2), 329-332 [10.1039/c6dt03876j].
Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells
Terenzi A.
2017-01-01
Abstract
Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.
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