The use of nanocomposites based on biopolymers and nanoparticles for controlled drug release is an attractive notion. We used halloysite nanotubes that were promising candidates for the loading and release of active molecules due to their hollow cavity. Gel beads based on chitosan with uniformly dispersed halloysite nanotubes were obtained by a dropping method. Alginate was used to generate a coating layer over the hybrid gel beads. This proposed procedure succeeded in controlling the morphology at the mesoscale and it had a relevant effect on the release profile of the model drug from the nanotube cavity.

Lisuzzo L., Cavallaro G., Parisi F., Milioto S., Fakhrullin R., Lazzara G. (2019). Core/shell gel beads with embedded halloysite nanotubes for controlled drug release. COATINGS, 9(2), 70-77 [10.3390/COATINGS9020070].

Core/shell gel beads with embedded halloysite nanotubes for controlled drug release

Lisuzzo L.
Investigation
;
Cavallaro G.
Conceptualization
;
Parisi F.
Conceptualization
;
Milioto S.
Conceptualization
;
Lazzara G.
Conceptualization
2019-01-01

Abstract

The use of nanocomposites based on biopolymers and nanoparticles for controlled drug release is an attractive notion. We used halloysite nanotubes that were promising candidates for the loading and release of active molecules due to their hollow cavity. Gel beads based on chitosan with uniformly dispersed halloysite nanotubes were obtained by a dropping method. Alginate was used to generate a coating layer over the hybrid gel beads. This proposed procedure succeeded in controlling the morphology at the mesoscale and it had a relevant effect on the release profile of the model drug from the nanotube cavity.
https://res.mdpi.com/coatings/coatings-09-00070/article_deploy/coatings-09-00070-v3.pdf?filename=&attachment=1
Lisuzzo L., Cavallaro G., Parisi F., Milioto S., Fakhrullin R., Lazzara G. (2019). Core/shell gel beads with embedded halloysite nanotubes for controlled drug release. COATINGS, 9(2), 70-77 [10.3390/COATINGS9020070].
File in questo prodotto:
File Dimensione Formato  
Coatings2019.pdf

accesso aperto

Descrizione: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Tipologia: Versione Editoriale
Dimensione 1.53 MB
Formato Adobe PDF
1.53 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/391560
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 48
  • ???jsp.display-item.citation.isi??? 47
social impact